Journal of Assisted Reproduction and Genetics

, Volume 15, Issue 8, pp 478–484 | Cite as

The Effects of Gonadotropin-Releasing Hormone Agonist on Androstenedione Production and Follicular Development During Controlled Ovarian Hyperstimulation

  • Kouichi Akaboshi
  • Takahisa Oda
  • Joji Yoshida
  • Satoshi Kohriyama
  • Toyohiko Miyazaki
  • Yasunori Yoshimura


Purpose: We performed a prospective randomized study to assess the effects of a GnRH agonist (GnRH-a) onfollicular development and steroidogenesis during controlled ovarian hyperstimulation (COH).

Methods: Patients undergoing in vitro fertilization (IVF)for tubal infertility received human menopausal gonadotropin (hMG) stimulation with or without the GnRH-a, buserelin, beginning in the midluteal phase of the prior cycle. We analyzed serum hormone levels, follicular development, and outcome of IVF.

Results: The mean number of retrieved oocytes was significantly greater, and the implantation rate per embryo was significantly higher, in the GnRH-a/hMG group (n = 101) than in the hMG-only group (n = 97). The concentration of androstenedione (A) and the A/estradiol ratio in the serum were significantly lower in the GnRH-a treatment group throughout the follicular phase.

Conclusions: The concomitant use of GnRH-a during COH prevents atretic change of the follicles and enhances follicular development by reducing androgen accumulation, resulting in a higher developmental competence of the oocytes.

androstenedione controlled ovarian hyperstimulation follicular atresia gonadotropin-releasing hormone agonist in vitro fertilization 


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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Kouichi Akaboshi
    • 1
  • Takahisa Oda
    • 1
  • Joji Yoshida
    • 1
  • Satoshi Kohriyama
    • 1
  • Toyohiko Miyazaki
    • 2
  • Yasunori Yoshimura
    • 2
  1. 1.Department of Obstetrics and GynecologyTokyo Dental College, Ichikawa General HospitalIchikawa CityJapan
  2. 2.Department of Obstetrics and GynecologyKeio University School of MedicineJapan

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