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Outcome of IVF in Patients with Endometriosis in Comparison with Tubal-Factor Infertility

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Abstract

Purpose: The aim of this retrospective study was to compare the outcome of in vitro fertilization and embryo transfer in women with endometriosis and a control group with tubal-factor infertility.

Methods: Forty-eight patients with endometriosis underwent 65 cycles of in vitro fertilization and embryo transfer at Huddinge University Hospital. The matched control group with tubal-factor infertility consisted of 98 cycles in 98 patients. These groups were retrospectively analyzed regarding stimulation, fertilization, embryo development, implantation, and pregnancy outcome.

Results: The fertilization rate was significantly lower in women with endometriosis, but the cleavage, implantation, and pregnancy rates did not differ.

Conclusions: Our results show that women with endometriosis have a lower fertilization rate compared with women with tubal-factor infertility. However, once the oocyte is fertilized, it seems that the preembryo has a normal chance of implantation, leading to similar pregnancy rates.

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REFERENCES

  1. Arici A, Oral E, Bukulmez O, Duleba A, Olive DL, Jones EE: The effect of endometriosis on implantation: results from the Yale University in vitro fertilization and embryo transfer program. Fertil Steril 1996;65:603-607

    Google Scholar 

  2. Hill JA: Immunologic factors in endometriosis and endometriosis-associated reproductive failure. Infert Reprod Med Clin North Am 1992;3:583-596

    Google Scholar 

  3. Gleicher N: Endometriosis, a new approach is needed. Hum Reprod 1992;7:821-824

    Google Scholar 

  4. Shushan A, Eisenberg VH, Schenker JG: Subfertility in the era of assisted reproduction: Changes and consequences. Fertil Steril 1995;64:459-469

    Google Scholar 

  5. Mahmood TA, Arumugam K, Templeton AA: Oocyte and follicular fluid characteristics in women with mild endometriosis. Br J Obstet Gynecol 1991;8:573-577

    Google Scholar 

  6. Olivennes F, Feldberg D, Liu HC, Cohen J, Moy F, Rosenwaks Z: Endometriosis: A stage by stage analysis-the role of in vitro fertilization. Fertil Steril 1995;64:392-398

    Google Scholar 

  7. Geber S, Paraschos T, Atkinson G, Margara R, Winston RML: Results of IVF in patients with endometriosis: The severity of the disease does not affect the outcome, or the incidence of miscarriage. Hum Reprod 1995;10:1507-1511

    Google Scholar 

  8. Wardle PG, McLaughlin EA, McDermot A, Mitchell JD, Ray BD, Hull MGR: Endometriosis and ovulatory disorder: reduced fertilization in vitro compared with tubal and unexplained infertility. Lancet 1985;2:236-239

    Google Scholar 

  9. Yovich JL, Yovich JM, Tuvik AI, Matson PL, Willcox DL: In-vitro fertilization for endometriosis. Lancet 1985;2:552 (Letter)

    Google Scholar 

  10. O'Shea RT, Chen C, Weiss T, Jones WR: Endometriosis and in-vitro fertilization. Lancet 1985;2:723.8 (Letter)

    Google Scholar 

  11. Wardle PG, Foster PA, Mitchell JD, McLaughlin EA, Sykes JA, Corrigan E, Hull MG, Ray BD, McDermott A: Endometriosis and IVF: Effect of prior therapy. Lancet 1986;1:276-277

    Google Scholar 

  12. Badaway SZA, Cuenca V, Marshall L, Munchback R, Rinas AC, Coble DA: Cellular components in peritoneal fluid in infertile patients with and without endometriosis. Fertil Steril 1984;42:704-708

    Google Scholar 

  13. Halme J, Becher S, Hammond M, Raj HMG, Raj S: Increased activation of pelvic macrophages in infertile women with mild endometriosis. Am J Obstet Gynecol 1983;145:333-337

    Google Scholar 

  14. Olive DL, Weinberg JB, Haney AF: Peritoneal macrophages and infertility: The association between cell number and pelvic pathology. Fertil Steril 1985;44:772-777

    Google Scholar 

  15. Dunselman GAJ, Hendrix MGR, Bouckaert PXJM, Evers JLH: Functional aspects of peritoneal macrophages in endometriosis of women. J Reprod Fertil 1988;82:707-710

    Google Scholar 

  16. Anderson DJ, Hill JA: Cell-mediated immunity in infertility. Am J Reprod Immunol Microbiol 1988;17:22-30

    Google Scholar 

  17. Sueldo CE, Lambert H, Steinleitner A, Rathwick, G, Swanson JA: The effect peritoneal fluid from patients with endometriosis on murine sperm-oocyte interaction. Fertil Steril 1987;48:697-699

    Google Scholar 

  18. Akoum A, Lemay A, Paradis I., Rheault N, Maheux R: Secretion of interleuikin-6 by human endometric cells and regulation by proinflammatory cytokines and sex steroids. Hum Reprod 1996;11:2269-2275

    Google Scholar 

  19. Bergquist A, Nejaty H, Fröjsa B, Bruce C, Sjöblom P, Söder O. Production of interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor (TNF) α in separated and cultured stromal and epithelial cells from endometriotic tissue and endometriosis. Mol Human Reprod 1998. (accepted for publication)

  20. Rana N, Braun DP, House R, Gebel H, Rotman C, Dmowski WP: Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis. Fertil Steril 1996;65:925-930

    Google Scholar 

  21. Sueldo CE, Kelly E, Montoro L, Subias E, Baccaro M, Swanson J, Steinleitner A, Lambert H: Effect of interleukin-1 on gamete interaction and mouse embryo development. J Reprod Med 1990;35:868-872

    Google Scholar 

  22. Tasdemir M, Tasdemir I, Kodama H, Tanaka T: Effect of peritoneal fluid from infertile women with endometriosis on ionophore-stimulated acrosome loss. Hum Reprod 1995;10:2419-2422

    Google Scholar 

  23. Arumugam K: Endometriosis and fertility: Raised iron concentration in the peritoneal fluid and its effect on the acrosome reaction. Hum Reprod 1994;9:1153-1157

    Google Scholar 

  24. Aeby TC, Huang T, Nakayama RT: The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro. Am J Obstet Gynecol 1996;174:1779-1783

    Google Scholar 

  25. Steinleitner A, Lambert H, Roy S: Immunomodulation with pentoxifylline abrogates macrophage-mediated infertility in an in vivo model: A paradigm for a novel approach to the treatment of endometriosis-associated subfertility. Fertil Steril 1991;55:26-31

    Google Scholar 

  26. Tanbo T, Omland A, Dale PO, Abyholm T: In vitro fertilization/embryo transfer in unexplained infertility and minimal peritoneal endometriosis. Acta Obstet Gynecol Scand 1995;74:539-543

    Google Scholar 

  27. Brizek CL, Schlaff S, Pellegrini VA, Frank JB, Worrilow KC: Increased incidence of aberrant morphological phenotypes in human embryogenesis—an association with endometriosis. J Assist Reprod Genet 1995;12:106-112

    Google Scholar 

  28. Gutiérrez A, Oliveira N, Cano F, Ruiz A, Simon C, Remohi J, Pellicer A: In vitro fertilization in infertile patients with endometriosis. Assist Reprod Rev 1994;4:162-171

    Google Scholar 

  29. Dmowski WP: Immunological aspects of endometriosis. Int J Gynecol Obstet 1995;50(Suppl. 1):3-10

    Google Scholar 

  30. Simón C, Gutiérrez A, Vidal A, de los Santos MJ, Tarin JJ, Remohi J, Pellicer A: Outcome of patients with endometriosis in assisted reproduction: Results from in-vitro fertilization and oocyte donation. Hum Reprod 1994;9:725-729

    Google Scholar 

  31. Palmisano GP, Adamson GD, Lamb EJ. Can staging systems for endometriosis based on anatomic location and lesion type predict pregnancy rates? Int J Fertil 1993;38:241-249

    Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden

    Annica Bergendal, Sophie Naffah, Christina Nagy, Agneta Bergqvist, Peter Sjöblom & Torbjörn Hillensjö

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  1. Annica Bergendal
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  2. Sophie Naffah
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  3. Christina Nagy
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  4. Agneta Bergqvist
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  5. Peter Sjöblom
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  6. Torbjörn Hillensjö
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Bergendal, A., Naffah, S., Nagy, C. et al. Outcome of IVF in Patients with Endometriosis in Comparison with Tubal-Factor Infertility. J Assist Reprod Genet 15, 530–534 (1998). https://doi.org/10.1023/A:1022526002421

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  • DOI: https://doi.org/10.1023/A:1022526002421

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