Bruchins, Plant Mitogens from Weevils: Structural Requirements for Activity
- 93 Downloads
Bruchins are 3-hydroxypropanoate esters of long-chain α,ω-diols from pea weevils and cowpea weevils that have been shown to initiate callus formation on pea pods at extremely low application rates. Synthetic analogs have been prepared and examined to evaluate structural requirements for inducing this unusual neoplastic response. Chain length (optimum length C22–C24) is important, whereas unsaturation within the chain is relatively unimportant. Difunctionality is required for maximum activity, but the α,ω-diols themselves are inactive. Most critical is the ester portion(s) of the molecules; 3-hydroxypropanoate esters are far more active than any analogs examined.
Unable to display preview. Download preview PDF.
- Berdnikov, V. A., Trusov, Y. A., Bogdanova, V. S., Kosterin, O. E., Rozov, S. M., Nedel'kina, S. V., and Nikulina, Y. N. 1992. The neoplastic pod gene (Np) may be a factor for resistance to the pest Bruchis pisorum L. Pisum Genet. 24:37–39.Google Scholar
- SNOAD, B. and MATTHEWS, P. 1969. Neoplasms of the pea pod, pp. 126–131, in C. D. Darlington and K. R. Lewis (eds.)., Chromosomes Today. Oliver Boyd, Edinburgh.Google Scholar