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Study of the Supramolecular Inclusion of β-Cyclodextrin with Andrographolide

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Abstract

An inclusion complex of β-cyclodextrin with andrographolide (Andro) was prepared by using a convenient new method of microwave irradiation. The structure of the inclusion complex was determined by UV and IR analyses as well as 1H NMR, 13C NMR and two dimensional NOE spectroscopic measurements. The results indicated that the possible stoichiometry of complex formation is 1:1 (guest:host ratio) and the two isomeric 1:1 inclusion complexes are present simultaneously in solution. Thermal studies proved the thermal stability of the inclusion complex.

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Authors and Affiliations

  1. Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, People's Republic of China

    Dongyu Zhao, Kaijun Liao, Xueyi Ma & Xiaohua Yan

Authors
  1. Dongyu Zhao
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  2. Kaijun Liao
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  3. Xueyi Ma
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  4. Xiaohua Yan
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Zhao, D., Liao, K., Ma, X. et al. Study of the Supramolecular Inclusion of β-Cyclodextrin with Andrographolide. Journal of Inclusion Phenomena 43, 259–264 (2002). https://doi.org/10.1023/A:1021223407297

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