Abstract
The nitration of 2,3'-biquinolyls in concentrated sulfuric acid with an equivalent amount of nitric acid at room temperature takes place exclusively at the 2-quinolyl fragment with the formation of the 5- and 8-nitro derivatives or their mixtures. The nitration of the 1',4'-dihydro derivatives under these conditions leads to analogous compounds. Reduction of the nitrobiquinolyls gives the respective amines. Acylation of the latter leads to acylamino-2,3'-biquinolyls.
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Demidova, N.V., Aksenov, A.V. Investigations In the Field of 2,3'-Biquinolyl. 13. Regioselectivity in the Nitration of 2,3'-Biquinolyls and Their 1',4'-Dihydro Derivatives. Chemistry of Heterocyclic Compounds 38, 908–912 (2002). https://doi.org/10.1023/A:1020909227484
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DOI: https://doi.org/10.1023/A:1020909227484