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Comparative Analysis of Polymorphous Genes of Glutathione-S-Transferases in North-Western Populations of Russia—Healthy and Patients with Bronchial Asthma

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Abstract

The ratio between polymorphous variants of two glutathione S-transferase (M1 and T1) genes (GSTM1 and GSTT1) was studied in healthy people and patients with bronchial asthma (BA) from northwestern Russia. The relative risk of development of BA amounted to 8.5 (C1 95%: 3.623–10.956) in people with GSTM1 0/0,GSTT1 0/0 genotype. No statistically significant differences in distribution of GSTM1 and GSTT1 genotypes were revealed between male and female patients with BA as was among patients with different severity of the disease. Frequency of homozygous GSTM1 0/0 and GSTT1 0/0 differed between patients with the beginning of the disease at the age before and after 30 years. The relative risk of BA development with GSTM1 0/0, GSTT1 0/0 genotype was increased 9.6 times (CI 95%: 3.90–23.85) in patients younger than 30 years, while 3.6 times (CI 95%: 2.15–5.98), in patients older than 30 years.

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Authors and Affiliations

  1. State University, St. Petersburg, Russia

    O. G. Sideleva

  2. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg, Russia

    T. I. Ivashchenko, M. V. Aseev & V. S. Baranov

  3. Saint Olga Children's City Hospital, St. Petersburg, Russia

    A. V. Orlov

  4. Institute of Pulmonology, Pavlov State Medical University, St. Petersburg, Russia

    T. E. Gembitskaya & M. A. Petrova

Authors
  1. O. G. Sideleva
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  2. T. I. Ivashchenko
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  3. A. V. Orlov
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  4. T. E. Gembitskaya
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  5. M. A. Petrova
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  6. M. V. Aseev
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  7. V. S. Baranov
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Sideleva, O.G., Ivashchenko, T.I., Orlov, A.V. et al. Comparative Analysis of Polymorphous Genes of Glutathione-S-Transferases in North-Western Populations of Russia—Healthy and Patients with Bronchial Asthma. Journal of Evolutionary Biochemistry and Physiology 38, 285–290 (2002). https://doi.org/10.1023/A:1020780425859

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