Familial Risk Among Patients with Endometriosis
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Purpose: The objective of the present study was to determine the prevalence of endometriosis among the relatives of patients with confirmed endometriosis.
Methods: We analyzed the prevalence of endometriosis among first-, second-, and third-degree relatives in a group of 101 patients with varying symptoms related to endometriosis seen at two public hospitals and submitted to laparoscopy and/or laparotomy. The control group consisted of 43 women submitted to laparoscopy without a diagnosis of endometriosis.
Results: Among the patients with endometriosis, we detected nine families with a positive history of endometriosis, comprising one mother, six sisters, three aunts, and two cousins, as opposed to no case among the controls.
Conclusions: These data confirm a familial tendency for endometriosis and suggest that this disorder has a genetic basis.
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- 1.Ranney B: Endometriosis. IV. Hereditary tendency. Obstet Gynecol 1971;37:734-737Google Scholar
- 2.Simpson JL, Elias S, Malinak LR, Buttram TR: Heritable aspects of endometriosis. Am J Obstet Gynecol 1980;137:327-331Google Scholar
- 3.Lamb RNK, Hoffmann R, Nichols TR: Family trait analysis: A case-control study of 43 women with endometriosis and their best friends. Am J Obstet Gynecol 1986;154:596-601Google Scholar
- 4.Moen MH, Magnus P: The familial risk of endometriosis. Acta Obstet Gynecol Scand 1993;72:560-564Google Scholar
- 5.Kennedy SH, Mardon HJ, Barlow DH: The Oxford endometriosis gene study. In Abstracts of the 2nd International Meeting of the BFS, Glasgow, 1994, p 11Google Scholar
- 6.ASRM: Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 1997;67:817-820Google Scholar
- 7.Donadio N, Nobrega AC: Leiomyomata plus endometriosis: Simultaneous treatment with gestrinone and buserelin acetate before in vitro fertilization-embryo transfer. In Progress in the Management of Endometriosis, EM Coutinho, P Spinola, LH Moura (eds). London, New York, Parthenon, 1995, pp 135-137Google Scholar
- 8.Arnold LL, Meck JM, Simon JA: Adenomyosis: Evidence for genetic cause. Am J Med Genet 1995;55:505-506Google Scholar
- 9.Pandis N, Karaikos C, Bardi G, Sfikas K, Tserkezoglou A, Fotiou S, Heim S: Chromosome analysis of uterine adenomyosis. Cancer Genet Cytogenet 1995;80:118-120Google Scholar
- 10.Oziaik YY, Meloni Am, Surti U, Sandberg AA: Deletion 7q22 in uterine leiomyoma. A cytogenetic review. Cancer Genet Cytogenet 1993;71:1-6Google Scholar
- 11.Moen MH: Endometriosis in monozygotic twins. Acta Obstet Gynecol Scand 1994;73:59-62Google Scholar