Journal of Assisted Reproduction and Genetics

, Volume 15, Issue 10, pp 587–593 | Cite as

Follicular Fluid Insulin-like Growth Factor-I and Insulin-like Growth Factor–Binding Protein-1 and -3 Vary as a Function of Ovarian Reserve and Ovarian Stimulation

  • Laurel Stadtmauer
  • Andrea Vidali
  • Steven R. Lindheim
  • Mark V. Sauer


Purpose: Follicular fluid concentrations of insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein (BP)-1, and IGFBP-3 in 57 women undergoing in vitro fertilization and embryo transfer were examined to determine whether levels reflected differences in patients' exposure to gonadotropin stimulation and a diminished ovarian reserve.

Methods: Preovulatory follicular fluid was obtained from both gonadotropin-stimulated and unstimulated cycles. Subjects were grouped according to normal or decreased ovarian reserve and whether or not they received gonadotropin stimulation.

Results: The mean follicular fluid concentrations of IGF-I and IGFBP-1 were significantly lower in the “decreased” ovarian reserve group compared with the “normal” ovarian reserve group, with no change in estradiol or IGF-II levels. This resulted in a decreased molar IGF-I: BP ratio and an increased molar IGF-II:IGFBP-1 ratio. In unstimulated cycles, mean follicular fluid concentrations of IGFs did not differ significantly compared with those in stimulated cycles, whereas concentrations of IGFBP-1 and IGFBP-3 were significantly lower, leading to higher molar ratios of the IGFs to the binding proteins.

Conclusions: Follicular fluid IGF and binding proteins vary as a function of ovarian reserve and gonadotropin stimulation. This may reflect either differences in oocyte quality or a suboptimal follicular fluid environment.

follicular fluid insulin-like growth factors in vitro fertilization ovarian reserve 


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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Laurel Stadtmauer
    • 1
    • 2
  • Andrea Vidali
    • 1
  • Steven R. Lindheim
    • 1
  • Mark V. Sauer
    • 1
  1. 1.Department of Obstetrics and Gynecology, Division of Reproductive EndocrinologyCollege of Physicians and Surgeons, Columbia University, Columbia Presbyterian Medical CenterNew York
  2. 2.North Carolina Center for Reproductive MedicineCary

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