Abstract
Beckmann rearrangement of N-[3-(1-hydroxyimino)ethyl-2,2-dimethylcyclobutyl]acetylanthranilic acid, and its 5-bromo and 4-chloro derivatives gives the corresponding N-(3-acetylamino-2,2-dimethylcyclobutyl)acetylanthranilic acids. Treatment of these acylanthranilic acids with formamide gives 2-(3-acetylamino-2,2-dimethylcyclobutyl)methyl-4(3H)-quinazoline and its 6-bromo and 7-chloro derivatives.
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Avotin'sh, F.M., Petrova, M.V., Tonkikh, N.N. et al. 2-(3-Acetylamino-2,2-dimethylcyclobutyl)-methyl-4(3H)-quinazolinones. Chemistry of Heterocyclic Compounds 36, 1326–1328 (2000). https://doi.org/10.1023/A:1017579719809
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DOI: https://doi.org/10.1023/A:1017579719809