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Cyclocondensation of 3-Amino-1,2,4-triazoles with Esters of Substituted Cinnamic Acids and Aromatic Unsaturated Ketones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

We have studied the reactions of 3-amino, 3,5-diamino-, and 3-amino-5-trifluoromethyl-1,2,4-triazole with esters of substituted cinnamic acids and aromatic unsaturated ketones; we have established the directionality of formation of the tetrahydrooxopyrimidine ring. We have carried out hydrolysis and hydrazinolysis of 7-phenyl-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidin-5-one. We have conducted an X-ray diffraction study of isopropylidene hydrazide of 3-(5-amino-1,2,4-triazol-1-yl)-3-phenylpropionic acid.

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Authors and Affiliations

  1. Ukrainian Scientific-Research Institute of Pharmacotherapy of Endocrine Diseases, Kharkov, 61002

    V. V. Lipson, M. G. Shirobokova & V. N. Chernenko

  2. V. N. Karazin Kharkov National University, Kharkov, 61077, Ukraine

    S. M. Desenko, V. D. Orlov & L. I. Zinov'eva

  3. Institute of Single Crystals, Kharkov, 61001, Ukraine

    O. V. Shishkin

Authors
  1. V. V. Lipson
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  2. S. M. Desenko
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  3. V. D. Orlov
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  4. O. V. Shishkin
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  5. M. G. Shirobokova
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  6. V. N. Chernenko
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  7. L. I. Zinov'eva
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Lipson, V.V., Desenko, S.M., Orlov, V.D. et al. Cyclocondensation of 3-Amino-1,2,4-triazoles with Esters of Substituted Cinnamic Acids and Aromatic Unsaturated Ketones. Chemistry of Heterocyclic Compounds 36, 1329–1335 (2000). https://doi.org/10.1023/A:1017531803879

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  • DOI: https://doi.org/10.1023/A:1017531803879

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