Journal of Assisted Reproduction and Genetics

, Volume 19, Issue 8, pp 363–367 | Cite as

Intraindividual Hormonal Variability in Ultrasonographically Timed Successive Ovulatory Menstrual Cycles Is Detected Only in the Luteal Phase in Infertility Patients

  • Kamal OjhaEmail author
  • Sophie C. Barnes
  • Frances G. Boa
  • Stephen Moody
  • Povilas Sladkevicius
  • Geeta Nargund
  • Paul O. Collinson


Objective: To assess intraindividual variation of follicle stimulating hormone, luteinising hormone, estradiol, progesterone, inhibin A, and inhibin B in three successive ovulatory cycles correlated with transvaginal ultrasound monitored morphological changes in the ovary.

Methods: Serial transvaginal color and pulsed Doppler ultrasound and serum hormone analysis were performed during midfollicular, periovulatory, and midluteal phase for three consecutive cycles in 19 patients with normal menstrual cycles.

Results: Luteinising hormone and progesterone showed significant differences in the midluteal phase between the 1st and 2nd cycle (luteinising hormone p = 0.007 and progesterone p = 0.02). Progesterone showed a similar significant change (p = 0.013) between the 2nd and 3rd cycle. No significant differences were seen in the midfollicular or periovulatory phases or between the 1st and 3rd cycle.

Conclusions: Luteal phase progesterone and luteinising hormone concentrations showed individual variation in successive cycles suggesting early or late corpus luteolysis. Follicular and periovulatory hormone levels were similar in subsequent ovulatory cycles.

Intraindividual variation ovulatory cycles progesterone serum gonadotrophins 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Dodson KS, Coutts JRT, Macnaughton MC: Plasma sex steroid and gonadotrophin patterns in human menstrual cycles. Br J Obstet Gynaecol 1975;82:602-614Google Scholar
  2. 2.
    Dodson KS, Macnaughton MC, Coutts JRT: Infertility in womenwith apparently ovulatory cycles. I: Comparison of their plasma sex steroid and gonadotrophin profiles with those in the normal cycles. Br J Obstet Gynaecol 1975;82:615-624Google Scholar
  3. 3.
    Dodson KS, Macnaughton MC, Coutts JRT: Infertility in women with apparently ovulatory cycles. II: The effects of clomiphene treatment on the profiles of gonadotrophin and sex steroid hormones in peripheral plasma. Br J Obstet Gynaecol 1975;82:625-633Google Scholar
  4. 4.
    Sobowale O, Francis B, Lenton EA, Cooke ID: Comparison of plasma steroid and gonadotrophin profiles in spontaneous cycles in which conception did and did not occur. Br J Obstet Gynaecol 1978;85:460-467Google Scholar
  5. 5.
    Schweiger U, Tuschl R, Broocks A, Pirke KM: Gonadotrophin secretion in the second half of the menstrual cycle: A comparison of women with normal cycles, luteal phase defects and disturbed follicular development. Clin Endocrinol 1990;32: 25-32Google Scholar
  6. 6.
    Driessen F, Kremer J, Alsbach GP, de Kroon RA: Serum progesterone and oestradiol concentrations in women with unexplained infertility. Br J Obstet Gynaecol 1980;87(7):619-623Google Scholar
  7. 7.
    Zeleznik AJ: Modifications in gonadotrophin in signaling: A key to understanding ovarian cyclicity during the menstrual cycle. In Endocrine Basis of Reproductive Function, M. Filicori (ed), Bologna, Italy, Monduzzi Editore. 2000, pp 313-325Google Scholar
  8. 8.
    Nakano R: Serum gonadotrophin and sex steroid hormone levels during mid-follicular and mid-luteal phases in hyperprolactinaemic women with regular menstrual cycles. Br J Obstet Gynaecol 1987;94(2):142-146Google Scholar
  9. 9.
    Lenton EA, Lawrence GF, Coleman RA, Cooke ID: Individual variation in gonadotrophin and steroid concentrations and in the lengths of the follicular and luteal phases in women with regular menstrual cycles. Clin Reprod Fertil 1983;2(2):143-150Google Scholar
  10. 10.
    Groome NP, Illingworth PJ, O'Brien M, Cooke I, Ganesan TS, Baird DT, McNeilly AS: Detection of dimeric inhibin throughout the human menstrual cycle by two-site enzyme immunoassay. Clin Endocrinol (Oxf) 1994;40(6):717-723Google Scholar
  11. 11.
    Groome NP, Illingworth PJ, O'Brien M, Pai R, Rodger FE, Mather JP, McNeilly AS: Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab 1996;81(4):1401-1405Google Scholar
  12. 12.
    Lenton EA, de Kretser DM, Woodward AJ, Robertson DM: Inhibin concentrations throughout the menstrual cycles of normal, infertile, and older women compared with those during spontaneous conception cycles. J Clin Endocrinol Metab 1991;73(6):1180-1190Google Scholar
  13. 13.
    Muttukrishna S, Child T, Lockwood GM, Groome NP, Barlow DH, Ledger WL: Serum concentrations of dimeric inhibins, activin A, gonadotrophins and ovarian steroids during the menstrual cycle in older women. Hum Reprod 2000;15(3):549-556Google Scholar
  14. 14.
    Sehested A, Juul AA, Andersson AM, Petersen JH, Jensen TK, Muller J, Skakkebaek NE: Serum inhibin A and inhibin B in healthy prepubertal, pubertal, and adolescent girls and adult women: Relation to age, stage of puberty, menstrual cycle, follicle-stimulating hormone, luteinizing hormone, and estradiol levels. J Clin Endocrinol Metab 2000;85(4):1634-1640Google Scholar
  15. 15.
    Finn MM, Gosling JP, Tallon DF, Joyce LA, Meehan FP, Fottrell PF: Follicular growth and corpus luteum function in women with unexplained infertility, monitored by ultrasonography and measurement of daily salivary progesterone. Gynecol Endocrinol 1989;3(4):297-308Google Scholar
  16. 16.
    Geisthovel F, Skubsch U, Zabel G, Schillinger H, Breckwoldt M: Ultrasonographic and hormonal studies in physiologic and insufficient menstrual cycles. Fertil Steril 1983;39(3):277-283Google Scholar
  17. 17.
    Geisthovel F, Skubsch U, Zabel G, Schillinger H, Breckwoldt M: Ultrasonographic and endocrinological studies of ovarian function. Ultrasound Med Biol 1983;(Suppl 2):603-608Google Scholar
  18. 18.
    Cook CL, Rao CV, Yussman MA: Plasma gonadotropin and sex steroid hormone levels during early, midfollicular, and midluteal phases of women with luteal phase defects. Fertil Steril 1983;40(1):45-48Google Scholar

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Kamal Ojha
    • 1
    Email author
  • Sophie C. Barnes
    • 2
  • Frances G. Boa
    • 2
  • Stephen Moody
    • 2
  • Povilas Sladkevicius
    • 1
  • Geeta Nargund
    • 1
  • Paul O. Collinson
    • 2
  1. 1.Department of Obstetrics and GynecologyDiana, Princess of Wales Centre for Reproductive Medicine, St. George's Hospital Medical SchoolCranmer Terrace, Tooting, LondonUnited Kingdom
  2. 2.Department of Chemical PathologySt. George's HospitalLondonUnited Kingdom

Personalised recommendations