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Journal of Assisted Reproduction and Genetics

, Volume 19, Issue 8, pp 363–367 | Cite as

Intraindividual Hormonal Variability in Ultrasonographically Timed Successive Ovulatory Menstrual Cycles Is Detected Only in the Luteal Phase in Infertility Patients

  • Kamal OjhaEmail author
  • Sophie C. Barnes
  • Frances G. Boa
  • Stephen Moody
  • Povilas Sladkevicius
  • Geeta Nargund
  • Paul O. Collinson
Article

Abstract

Objective: To assess intraindividual variation of follicle stimulating hormone, luteinising hormone, estradiol, progesterone, inhibin A, and inhibin B in three successive ovulatory cycles correlated with transvaginal ultrasound monitored morphological changes in the ovary.

Methods: Serial transvaginal color and pulsed Doppler ultrasound and serum hormone analysis were performed during midfollicular, periovulatory, and midluteal phase for three consecutive cycles in 19 patients with normal menstrual cycles.

Results: Luteinising hormone and progesterone showed significant differences in the midluteal phase between the 1st and 2nd cycle (luteinising hormone p = 0.007 and progesterone p = 0.02). Progesterone showed a similar significant change (p = 0.013) between the 2nd and 3rd cycle. No significant differences were seen in the midfollicular or periovulatory phases or between the 1st and 3rd cycle.

Conclusions: Luteal phase progesterone and luteinising hormone concentrations showed individual variation in successive cycles suggesting early or late corpus luteolysis. Follicular and periovulatory hormone levels were similar in subsequent ovulatory cycles.

Intraindividual variation ovulatory cycles progesterone serum gonadotrophins 

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Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Kamal Ojha
    • 1
    Email author
  • Sophie C. Barnes
    • 2
  • Frances G. Boa
    • 2
  • Stephen Moody
    • 2
  • Povilas Sladkevicius
    • 1
  • Geeta Nargund
    • 1
  • Paul O. Collinson
    • 2
  1. 1.Department of Obstetrics and GynecologyDiana, Princess of Wales Centre for Reproductive Medicine, St. George's Hospital Medical SchoolCranmer Terrace, Tooting, LondonUnited Kingdom
  2. 2.Department of Chemical PathologySt. George's HospitalLondonUnited Kingdom

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