Journal of Assisted Reproduction and Genetics

, Volume 19, Issue 8, pp 394–397 | Cite as

Isolation and Expression Analysis of the Human RNH2 Gene Encoding Ribonuclease Inhibitor 2

  • Toshinobu Miyamoto
  • Shiga Hasuike


Ribonuclease inhibitor 1 (RI-1) is a cytoplasmic protein that inhibits a variety of pancreatic-type mammalian Rnases by forming a very tight, reversible 1:1 complex. Recently a novel gene encoding ribonuclease inhibitor 2, Rnh2 has been isolated in mouse. The expression pattern of the mouse Rnh2 is specific to testis, especially in the spermatogonia. Then it has been suggested that the mouse Rnh2 gene may play critical roles in mouse spermatogenesis. In this study, we isolated the human RNH2 cDNA and analyzed its expression pattern. The human RNH2 is also expressed limited to testis, and then it is suggested that the human Rnh2 gene may also play critical roles in human spermatogenesis.

RNH2 testis spermatogenesis 


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Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Toshinobu Miyamoto
    • 1
  • Shiga Hasuike
    • 1
  1. 1.Laboratory of Mammalian Genes and Development, National Institute of Child Health, and Human Development, NIHBethesda

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