Skip to main content
SpringerLink
Log in

1-(2-Quinoxalyl)-, 1-[3,5-Di(trifluoromethyl)phenyl]-, 1-(2-Carboxyphenyl)-, and 1-Ethoxycarbonyl-4-oxo-4,5,6,7-tetrahydroindazoles

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The corresponding 1-(2-quinoxalyl)-, 1-[3,5-di(trifluoromethyl)phenyl]-, and 1-ethoxycarbonyl-3-methyl-4-oxo-4,5,6,7-tetrahydroindazoles have been obtained from reactions of 2-acetyl-1,3-cyclohexanedione, its 5,5-dimethyl and 5-(2-furyl) derivatives, with 2-hydrazinoquinoxaline, 3,5-di(trifluoromethyl)phenylhydrazine, and ethoxycarbonylhydrazine. On interaction with ethoxycarbonylhydrazine the intermediate 2-[1-(β-ethoxycarbonyl)hydrazino]ethylidene-1,3-cyclohexanediones were also isolated. From the potassium salt of 2-formyldimedone and 2-carboxyphenylhydrazine hydrochloride, 2-(2-carboxyphenyl)hydrazinomethylene-5,5-dimethyl-1,3-cyclohexanedione was obtained, the cyclization of which in ethanol in the presence of HCl led to 1-(2-carboxyphenyl)- and 1-(2-ethoxycarbonylphenyl)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazole.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  1. M. K.-H. Doll, D. E. Nichols, J. D. Kilts, C. Prioleau, C. P. Lowler, M. M. Lewis, and R. B. Mailman, J. Med. Chem., 42, 935 (1999).

    Google Scholar 

  2. V. V. Sorokin, A. V. Grigor'ev, A. K. Ramazanov, and A. P. Kriven'ko, Khim. Geterotsikl. Soedin., 757 (1999).

  3. T. Mimura, N. Kato, T. Sugaya, M. Ikuta, S. Kato, Y. Kuge, S. Tomioka, and M. Kasai, Synthesis, 947 (1999).

  4. E.-S. A. M. Badawey and I. M. El-Ashmawey, Eur. Med. Chem., 33, 349 (1998).

    Google Scholar 

  5. L. Strekowski and Shon-Yuan Lin, J. Heterocycl. Chem., 34, 1625 (1997).

    Google Scholar 

  6. I. A. Strakova, A. Ya. Strakov, M. V. Petrova, and L. G. Delyatitskaya, Khim. Geterotsikl. Soedin., 533 (2000).

  7. I. A. Strakova, A. Ya. Strakov, and M. V. Petrova, Khim. Geterotsikl. Soedin., 351 (1995).

  8. A. Ya. Strakov, I. A. Strakova, and M. V. Petrova, Khim. Geterotsikl. Soedin., 708 (1996).

  9. A. Ya. Strakov, M. V. Petrova, A. Dishs, Yu. Popelis, and N. N. Tonkikh, Khim. Geterotsikl. Soedin., 234 (1997).

  10. A. Ya. Strakov, N. N. Tonkikh, M. V. Petrova, and I. A. Strakova, Khim. Geterotsikl. Soedin., 516 (1997).

  11. A. Ya. Strakov, N. N. Tonkikh, M. V. Petrova, and I. A. Strakova, Khim. Geterotsikl. Soedin., 1669 (1997).

  12. I. Strakova, A. Strakov, M. Strautzele, and E. Gudriniece, Izv. Akad. Nauk LatvSSR. Ser. Khim., 597 (1968).

Download references

Author information

Authors and Affiliations

  1. Riga Technical University, Riga, LV-1658, Latvia

    I. Strakova, A. Strakovs & M. Petrova

Authors
  1. I. Strakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Strakovs
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Petrova
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Strakova, I., Strakovs, A. & Petrova, M. 1-(2-Quinoxalyl)-, 1-[3,5-Di(trifluoromethyl)phenyl]-, 1-(2-Carboxyphenyl)-, and 1-Ethoxycarbonyl-4-oxo-4,5,6,7-tetrahydroindazoles. Chemistry of Heterocyclic Compounds 38, 429–433 (2002). https://doi.org/10.1023/A:1016079221645

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1016079221645

Search

Navigation