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Convenient Synthesis of 3-(1-Carboxyalkyl)pyrido[2,3-d]pyrimidine-2,4-diones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A cheap and safe synthetic route to obtain 3-(1-carboxyalkyl)pyrido[2,3-d]pyrimidinediones (carboxyalkyl = -CHRCO2H; R = H; CH2; CH2Ph; Ph; CH2 (C3H3N2); (CH2)2CO2H; CH2CO2H) starting from 2,3-pyridinedicarboxylic acid is described. A process scheme consistent with empirical observations is proposed.

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REFERENCES

  1. Youcef M. Rustum, Encyclopedia of CANCER, II, G-Q, 1327 (1997).

    Google Scholar 

  2. J. W. Bae, S. H. Lee, Y. Cho, Y. J. Jung, H-J. Hwang, and C. M. Yoon, Tetrahedron Lett., 41, 5899 (2000).

    Google Scholar 

  3. J. Quiroga, A. Hormaza, B. Insuasty, M. Noguera, A. Sanchez, N. Hanold, and H. Meier, J. Heterocycl. Chem., 34, 521 (1997).

    Google Scholar 

  4. H. Sladowska, M. Bodetko, M. Sieklucka-Dziuba, G. Rajtar, D. Zólkowska, and Z. Kleinrok., Farmaco, 52, 657 (1997).

    Google Scholar 

  5. S. Youssef, S. El-Bahaie, and E. Nabih, J. Chem. Res. (S), 521 (1999).

  6. G. Singh, Swati, A. K. Mishra, and L. Prakash, Indian J. Chem., 37, 517 (1998).

    Google Scholar 

  7. U. Urled, B. Stanovnik, and M. Tisler, J. Heterocycl. Chem., 27, 407 (1990).

    Google Scholar 

  8. Ph. M. Harrington, Heterocycles, 35, 683 (1993).

    Google Scholar 

  9. J. Weinstock, J. Org. Chem., 26, 3511 (1961).

    Google Scholar 

  10. C. Kaiser and J. Weinstock, Organic Syntheses, Coll., VI, 910, Wiley, New York (1988).

    Google Scholar 

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Authors and Affiliations

  1. Fac. of Sciences-Tetouan, Univ. Abdelmalek Essaadi, B. P. 2121, Tetouan, Morroco

    M. Saoud, F. B. Benabdelouahab & F. El Guemmout

  2. Area de Quimica Inorganica, Facultad de Ciencias, Universidad de Almeria, 04071, Almeria, Spain

    A. Romerosa

Authors
  1. M. Saoud
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  2. F. B. Benabdelouahab
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  3. F. El Guemmout
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  4. A. Romerosa
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Saoud, M., Benabdelouahab, F.B., Guemmout, F.E. et al. Convenient Synthesis of 3-(1-Carboxyalkyl)pyrido[2,3-d]pyrimidine-2,4-diones. Chemistry of Heterocyclic Compounds 38, 306–309 (2002). https://doi.org/10.1023/A:1015635303954

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