Biotechnology Letters

, Volume 24, Issue 10, pp 801–805 | Cite as

Insights into bactericidal action of surface-attached poly(vinyl-N-hexylpyridinium) chains

  • Jian Lin
  • Joerg C. Tiller
  • Sang Beom Lee
  • Kim Lewis
  • Alexander M. Klibanov
Article

Abstract

The surface of polyethylene slides nanocoated with silica and derivatized with long-chain poly(vinyl-N-hexylpyridinium) becomes permanently bactericidal: it kills 90–99% of (both airborne and waterborne) wild-type and antibiotic-resistant strains of the human pathogen Staphylococcus aureus. The material created was similarly lethal to strains expressing multidrug resistance pumps, the only known mechanism of resistance to cationic antiseptics.

antibacterial immobilized polycation polymer surfaces 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Jian Lin
    • 1
  • Joerg C. Tiller
    • 1
  • Sang Beom Lee
    • 1
  • Kim Lewis
    • 2
  • Alexander M. Klibanov
    • 1
  1. 1.Department of ChemistryMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Department of BiologyNortheastern UniversityBostonUSA

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