Abstract
We here report on a birth of a male, with normal karyotype, after frozen thawed blastocyst transfer following intracytoplasmic injection of frozen thawed testicular spermatozoa from an azoospermic 27-year-old man with nonmosaic Klinerfelter's syndrome. Testicular sperm were retrieved by percutaneous needle biopsy.
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REFERENCES
Bourne H, Stern K, Clarke G, Pertile M, Speirs A, Baker HWG: Delivery of normal twins following the intracytoplasmic injection of spermatozoa from a patient with 47,XXY Klinefelter's syndrome. Hum Reprod 1997;11:2447–2450
Palermo GD, Schlegel PN, Sills ES, Veeck LL, Zaninocic N, Menendez S, Rosenwaks Z: Births after intracytoplasmic injection of sperm obtained by testicular extraction from men with non-mosaic Klinefelter's syndrome. N Engl J Med 1998;338:588–590
Reubinoff BE, Abeliovich D, Werner M, Schenker JG, Lewin A:Abirth in a non-mosaic Klinefelter's syndrome after testicular fine needle aspiration, intracytoplasmic sperm injection and preimplantation genetic diagnosis.HumReprod 1998;13: 1887–1892
Rosenlund B, Kvist U, Plöen L, Ekström U, Hovatta O: Percutaneous cutting needle biopsies for histopathological assessment and sperm retrieval in men with azoospermia. Hum Reprod 2001;16:2154–2159
Cohen J, Simons RF, Edwards RG, Fehilly CB, Fishel SB: Pregnancies following the frozen storage of expanding human blastocysts. J In Vitro Fert Embry Transf 1985;2:59–64
Kaufmann RA, Menezo Y, Hazout A, Nicollet B, DuMont M, Servy EJ: Cocultured blastocyst cryopreservation: Experience of more than 500 transfer cycles. Fertil Steril 1995;64:1125–1129
Langley MT, Marek DM, Gardner DK, Doody KM, Doody KJ: Extended embryo culture in human assisted reproduction treatments. Hum Reprod 2001;6:902–908
Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB: Blastocyst score affects implantation and pregnancy outcome: Towards a single blastocyst transfer. Fertil Steril 2000;73: 1155–1158
Gardner DK, Vella P, Lane M, Vella P, Lane M, Wagley L, Schlenker T, Schoolcraft WB: Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers. Fertil Steril 1998;69:84–88
Milki AA, Fisch JD, Behr B:Two-blastocyst transfer has similar pregnancy rates and a decreased multiple gestation rate compared with three-blastocyst transfer. Fertil Steril 1999;72:225–228
Guttenbach M, Michelmann HW, Hinney B, Engel W, Schmid M: Segregation of sex chromosomes into sperm nuclei in a man with 47,XXY Klinefelter's karyotype: A FISH analysis. Hum Genet 1997;99:474–477
Foresta C, Galeazzi C, Bettella A, Stella M, Scandellari C: High incidence of sperm sex aneuploidies in two patients with Klinefelter's syndrome. J Clin Endocrinol Metab 1998;83:203–205
Levon J, Aviram-Goldring A, Madgar I, Raviv G, Barkai G, Dor J: Sperm chromosome analysis and outcome of IVF in patients with non-mosaic Klinefelter's syndrome. Fertil Steril 2000;5:925–929
Chevret E, Monteil M, Cozzi J, Pelletier R, Sele B: Excess of hyperhaploid, 24,XY spermatozoa in Klinefelter's syndrome detected by three-colour FISH procedure (Abstract). Fertil Steril 1995;64(Suppl):S235
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Rosenlund, B., Hreinsson, J.G. & Hovatta, O. Birth of a Healthy Male After Frozen Thawed Blastocyst Transfer Following Intracytoplasmic Injection of Frozen Thawed Testicular Spermatozoa from a Man with Nonmosaic Klinefelter's Syndrome. J Assist Reprod Genet 19, 149–151 (2002). https://doi.org/10.1023/A:1014792922874
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DOI: https://doi.org/10.1023/A:1014792922874