Abstract
Thermoinactivation is under investigation as a new method of cancer treatment. Prior histopathologic verification has been indispensable. Our experiments show that thermoinactivation is in principle possible without destroying histopathologic morphology, if the temperature stays within certain limits. It could thus become applicable already before diagnostic biopsy, which might be used to avoid any potential spread during biopsy and before definitive surgery.
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Moreno JG, O'Hara SM, Long JP, Veltri RW, Ning X, Alexander AA, Gomella LG: Transrectal ultrasound-guided biopsy causes hematogenous dissemination of prostate cells as determined by RT-PCR. Urology 49(4): 515–520, 1997
Louha M, Nicolet J, Zylberberg H, Sabille A, Vons C, Vona G, Poussin K, Tournebize M, Capron F, Pol S, Franco D, Lacour B, Bréchot C, Paterlini-Bréchot P: Liver resection and needle liver biopsy cause hematogenous dissemination of liver cells. Hepatology 29: 879–882, 1999
Miyazono F, Takao S, Natsugoe S, Uchikura K, Kijima F, Aridome K, Shinchi H, Aikou T: Molecular detection of circulating cancer cells during surgery in patients with biliarypancreatic cancer. Am J Surg 177: 475–479, 1999
Heywang-Köbrunner SH, Heinig A, Weiwad W: New insights into tumor cell inactivation and histopathologic assessment after radiofrequency treatment: case report and in vitro test of a new hypothesis. Radiologe 41: 478–483, 2001
Hall-Craggs MA: Interventional MRI of the breast: Minimally invasive therapy. Eur Radiol 10: 59–62, 2000
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Heywang-Köbrunner, S.H., Weiwad, W., Lampe, D. et al. Preservation of histopathologic assessment by use of a special technique for tissue inactivation by radiofrequency. Breast Cancer Res Treat 71, 85–88 (2002). https://doi.org/10.1023/A:1013379206222
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DOI: https://doi.org/10.1023/A:1013379206222