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Synthesis and Alkylation of 4-(2-Chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethylpiperidin-2-thione

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

4-(2-Chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethylpiperidin-2-thione, which was used for the synthesis of 2-allylthio-4-(2-chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine, was obtained by the reaction of 2-thienoyltrifluoroacetone with 2-chlorophenylphenylmethylenecyanothioacetamide or with a mixture of 2-chlorobenzaldehyde and cyanothioacetamide in the presence of N-methylmorpholine. The molecular and crystal structure of the piperidinthione have been established by X-ray crystallography.

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Authors and Affiliations

  1. Taras Shevchenko Lugansk State Pedagogical University, Lugansk, 34801, Ukraine

    S. G. Krivokolysko & V. D. Dyachenko

  2. Institute of Organic Chemistry, Ukraine National Academy of Sciences, Kiev, 253660, Ukraine

    E. B. Rusanov

  3. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 117913, Russia

    V. P. Litvinov

Authors
  1. S. G. Krivokolysko
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  2. V. D. Dyachenko
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  3. E. B. Rusanov
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  4. V. P. Litvinov
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Krivokolysko, S.G., Dyachenko, V.D., Rusanov, E.B. et al. Synthesis and Alkylation of 4-(2-Chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethylpiperidin-2-thione. Chemistry of Heterocyclic Compounds 37, 987–992 (2001). https://doi.org/10.1023/A:1012739601781

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  • DOI: https://doi.org/10.1023/A:1012739601781

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