Abstract
The synthesis has been achieved of a series of 9-substituted derivatives of 6-(4-nitroimidazol-5-yl)- and 6-(5-nitroimidazol-4-yl)thiopurines by the reaction of 6-(nitroimidazolyl)thiopurines with alkyl and aralkyl halides, haloalcohols, haloacids and their esters, halo ketones, halo aldehyde acetals, and arylsulfonate esters using potassium carbonate in DMF.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
A. H. Chalmers, P. R. Knight, and M. R. Atkinson, Austr. J. Exp. Biol. Med. Sci., 47, 263 (1969); Chem. Abstr.,70, 103182 (1969).
P. M. Kochergin, E. V. Aleksandrova, and V. S. Korsunskii, Khim. Geterotsikl. Soedin., 372 (2000).
J. Montgomery and C. Temple, J. Am. Chem. Soc., 83, 630 (1961).
D. Brown and P. Ford, J. Chem. Soc. (C), 2620 (1969).
E. D. Kaverzneva, V. K. Zvorykina, and V. V. Kiseleva. Izv. Akad. Nauk SSSR., Ser. Khim., 2295 (1970).
Ya. Ya. Shluke, B. V. Zarinya, M. Yu. Lidak, and Yu. P. Shvachkin, Khim. Geterotsikl. Soedin., 534 (1970).
N. D. Gracheva, A. Ya. Veinberg, and G. I. Samokhvalov, Zh. Obshch. Khim., 41, 1376 (1971).
V. S. Korsunskii, P. M. Kochergin, and V. S. Shlikhunova, Khim.-Farm. Zh., 23, 249 (1989).
P. M. Kochergin, Khim. Geterotsikl. Soedin., 761 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Aleksandrova, E.V., Kochergin, P.M., Persanova, L.V. et al. Synthesis of 9-Substituted Derivatives of 6-(Nitroimidazolyl)thiopurines. Chemistry of Heterocyclic Compounds 37, 610–614 (2001). https://doi.org/10.1023/A:1011612823352
Issue Date:
DOI: https://doi.org/10.1023/A:1011612823352