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Effectiveness of Low Dose of Gonadotropin Releasing Hormone Agonist on Hormonal Flare-Up

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Abstract

Purpose: The hormonal response (flare-up) followingadministration of a standard dose (100 μg) or a low dose(25 μg) of gonadotropin releasing hormone agonist(GnRH-a) (Triptorelin) was compared in patients prior to an in vitrofertilization (IVF) cycle and during the early follicular phaseof a short-term IVF protocol.

Methods: The gonadotroph (FSH, LH) and steroid [estradiol(E2) and progesterone (P)] flare-up was studied on twoconsecutive cycles in 30 normo-ovulatory women. Patientswere randomized to receive either 25 or 100 μg of triptorelinfor three days at the beginning of the first cycle. Then doseswere switched according to a crossing over design in thesecond cycle.

Results: No significant difference in the magnitude of FSHand E2 release could be observed following administrationof the two doses of agonist whereas maximal plasma LHlevel was significantly reduced after injection of 25 μg oftriptorelin.

Conclusions: As compared to a standard dose, using a lowdose of GnRH-a induces an hormonal flare-up which seemsadequate for an optimal follicular recruitment.

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Authors and Affiliations

  1. Reproductive Medicine Unit, Department of Gynaecology and Obstetrics, Jean Verdier Hospital, University Paris XIII, Bondy, 93143, France

    Bettina Bständig

  2. Reproductive Medicine Unit, Department of Gynaecology and Obstetrics, Jean Verdier Hospital, University Paris XIII, Bondy, 93143, France

    Isabelle Cédrin-Durnerin & Jean Noël Hugues

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  1. Bettina Bständig
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  2. Isabelle Cédrin-Durnerin
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  3. Jean Noël Hugues
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Bständig, B., Cédrin-Durnerin, I. & Hugues, J.N. Effectiveness of Low Dose of Gonadotropin Releasing Hormone Agonist on Hormonal Flare-Up. J Assist Reprod Genet 17, 113–117 (2000). https://doi.org/10.1023/A:1009470101732

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