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The Effects of E2 Supplementation from the Early Proliferative Phase to the Late Secretory Phase of the Endometrium in hMG-Stimulated IVF-ET

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Abstract

Purpose: Our purpose was to determine if pregnancy rates(PRs) for hMG (human menopausalgonadotropin)-stimulated IVF-ET (in vitro ferilization-embryo transfer) can beincreased by estradiol (E2) supplementation from the earlyproliferative phase to the late secretory phase of theendometrium.

Method: Eighty-one infertile women with pure tubal factorwere randomized into two groups. One group received noE2 supplementation (control group) and the other receivedoral E2 supplementation (2 mg two times daily) from theearly proliferative phase starting on the third day of themenstrual cycle to the late secretory phase of theendometrium, with hMG stimulation for ovulation induction startingon the sixth day of the menstrual cycle.

Results: In 85 cycles, at least one embryo was transferred.Compared with the control group (n = 27 cycles), the E2supplementation group (n = 58 cycles) had a significantlyhigher PR (control, 25.9%, versus E2 supplementation,48.3%) and IR per ET (control, 10%, versus E2supplementation, 26%), but FRs per retrieved oocytes were notstatistically different between the two groups (control, 74%, versusE2 supplementation group, 73%). Four spontaneousabortions occurred in the E2 supplementation group, and onecase in the control group. Ectopic pregnancy occurred inone case in the control group.

Conclusions: Clinical PRs and IRs in the E2supplementation group were significantly higher than in the controlgroup, while FRs in the control group did not differstatistically from the E2 supplementation group. This suggests thatE2 supplementation from the early proliferative phase to thelate secretory phase of the endometrium in hMG-stimulatedIVF-ET increases the receptivity of the endometrium fortransferred embryos and clinical PRs.

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  1. Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Kwangju, pKorea

    >Hyuk Jung & Hyoung Kyun Roh

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  1. >Hyuk Jung
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Jung, >., Roh, H.K. The Effects of E2 Supplementation from the Early Proliferative Phase to the Late Secretory Phase of the Endometrium in hMG-Stimulated IVF-ET. J Assist Reprod Genet 17, 28–33 (2000). https://doi.org/10.1023/A:1009445913156

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