Abstract
Purpose: To determine whether there was any difference inthe outcome of in vitro fertilization when retrieval of oocyteswas done 34 hr (group A) or 38 hr (group B) after hCGinjection.
Methods: A total of 170 patients with tubal failure wererandomized into either group A (83 patients) or group B(87 patients). They underwent in vitro fertilization accordingto described protocols and were compared with regard tothe frequency of spontaneous ovulation, number of oocytesretrieved, oocyte cumulus complex quality, embryo quality,and implantation and pregnancy rates.
Results: There was no significant difference for any of theparameters tested for in group A and group B.
Conclusions: HCG can be administered at any time withinthe time interval of 34 to 38 hr before retrieval of oocyteswithout affecting the results of in vitro fertilization.
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REFERENCES
Steptoe PC, Edwards RG: Laparoscopic recovery of preovulatory human oocytes after priming of ovaries with gonadotropins. Lancet 1970;1:683–689
Flemming R., Coutts JR: Induction of multiple follicular growth in normally menstruating women with endogenous gonadotropin suppression. Fertil Steril 1986;45:226–230
Al-Mizyen ESS, Balet R, Lower AM, Wilson C, McClure A.F, Al-Shawaf T, Grundzinskas JG: Unexpected successful fertilization in vitro of oocytes retrieved 60 hours after human chorionic gonadotrophin injection. Hum Reprod 1998;4:1020–1021
De Vits A, Gerris J, Joostens M, Aytos A: Comparison between two hCG-to-oocyte aspiration intervals (36 versus 38) on the outcome of in-vitro fertilization. Hum Reprod 1994;9 (Suppl 4):12–
Van den Abbeel E, Van der Elst J, Van Waesberghe L, Camus M, Devroey P, Kahn I, Smitz J, Staessen C, Wisanto A, Van Steirteghem A: Hyperstimulation: The need for cryopreservation of embryos. Hum Reprod 1988;3 (Suppl 2):53–57
Åbyholm T, Tanbo T, Dale PO: The first attempt at IVF treatment. Results and requirement for satisfactory success rate. Eur J Obstet Gynecol Reprod Biol 1990;38:125–132
Tanbo T, Omland A, Dale PO: In vitro fertilization/embryo transfer in unexplained infertility and minimal peritoneal endometriosis. Acta Obstet Gynecol Scand 1995;74:539–543
Edwards RG, Fishel SB, Cohen J: Factors influencing the success of in vitro fertilization for alleviating human infertility. J In Vitro Fertil Embryo Transfer 1984;1:3–23
Trounson AO, Mohr LR, Wood C, Leeton JF: Effect of delayed insemination on in vitro fertilization, culture and transfer. J Reprod Fertil 1982;64:285–194
Edwards RG, Steptoe P: Indication of follicular growth, ovulation and luteinization in the human ovary. J Reprod Fertil 1975;22:121–163
McIntosh JEA, Matthews CD, Crocker JM, Broom TJ, Cox LW: Predicting the luteinizing hormone surge: Relationship between the duration of the follicular and luteal phases and the length of the human menstrual cycle. Fertil Steril 1980;34:125–130
Hoff JD, Quigley ME, Yen SSC: Hormonal dynamics in mid-cycle: A reevaluation. J Clin Endocrinol Metab 1983;57:792–796
Testart J, Frydman R: Minimum time lapse between luteinizing hormone surge or human chorionic gonadotropin administration and follicle rupture. Fertil Steril 1982;37:50–53
Hillier SG, Wickings EJ. Cellular aspects of corpus luteum function. In The Luteal Phase, SL Jeffcoate (ed). Chichester, John Wiley, 1985, pp 1–23
McNatty KP, Moore-Smith D, Makris A, Osathanondh R, Ryan KJ: The microenvironment of the human antral follicle: Interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro. J Clin Endocrinol Metab 1979;49:851–860
Richards JS: Maturation of ovarian follicles: Actions and interactions of pituitary and ovarian hormones on follicular cell differentiation. Physiol Rev 1980;60:51–89
Peters H, McNatty KP: The Ovary. London, Granada Publishing, 1980
Flemming R, Coutts JRT: Induction of multiple follicular development for IVF. In Assisted Human Conception, Vol 46, RG Edwards (ed). pp 596–615
Van Steirteghem AC, Liu J, Joris H: Higher success rate by ICSI than by subzonal insemination. A report of a second series of 300 consecutive treatment cycles. Hum Reprod 1993;8:1055–1060
Gudmundsson J, Fleming R, Jamieson ME: Luteinization oocyte retrieval delay in women in whom multiple follicular growth was induced as part of an in vitro fertilization/gamete intrafallopian transfer program. J Fertil Steril 1990;53:735–737
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Bjercke, S., Tanbo, T., Dale, P.O. et al. Comparison Between Two hCG-to-Oocyte Aspiration Intervals on the Outcome of In Vitro Fertilization. J Assist Reprod Genet 17, 319–322 (2000). https://doi.org/10.1023/A:1009401027251
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DOI: https://doi.org/10.1023/A:1009401027251