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Population balance model of in vivo neutrophil formation following bone marrow rescue therapy

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Abstract

In this paper, we develop a simple four parameter population balance model of in vivo neutrophil formation following bone marrow rescue therapy. The model is used to predict the number and type of neutrophil progenitors required to abrogate the period of severe neutropenia that normally follows a bone marrow transplant. The estimated total number of 5 billion neutrophil progenitors is consistent with the value extrapolated from a human trial. The model provides a basis for designing ex vivo expansion protocols.

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Authors and Affiliations

  1. Department of Chemical Engineering, The University of, Queensland, Brisbane, QLD 4072, Australia

    L. K. Nielsen

  2. Nexell Therapeutics Inc, Irvine, CA, U.S.A

    J. G. Bender

  3. Department of Chemical Engineering, Northwestern University, IL, U.S.A

    W. M. Miller & E. T. Papoutsakis

Authors
  1. L. K. Nielsen
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  2. J. G. Bender
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  3. W. M. Miller
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  4. E. T. Papoutsakis
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Correspondence to L. K. Nielsen.

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Nielsen, L.K., Bender, J.G., Miller, W.M. et al. Population balance model of in vivo neutrophil formation following bone marrow rescue therapy. Cytotechnology 28, 157–162 (1998). https://doi.org/10.1023/A:1008098118491

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  • DOI: https://doi.org/10.1023/A:1008098118491

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