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In situ hybridization: A possible diagnostic aid in leptomeningeal metastasis

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Abstract

In this review we discuss the clinical features and pathophysiology of leptomeningeal metastasis (LM), and elaborate on diagnostic tools for the detection of this serious complication of cancer. Because of the low sensitivity of the cytologic examination, new diagnostic approaches have been developed. The in situ hybridization technique may prove to be a reliable and early test for the detection of LM.

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Authors and Affiliations

  1. Department of Neurology, University Hospital Maastricht, The Netherlands

    R.J. van Oostenbrugge & A. Twijnstra

  2. Department of Molecular Cell Biology and Genetics, University of Maastricht, The Netherlands

    A.H.N. Hopman & F.C.S. Ramaekers

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  1. R.J. van Oostenbrugge
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  2. A.H.N. Hopman
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  3. F.C.S. Ramaekers
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  4. A. Twijnstra
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Oostenbrugge, R.v., Hopman, A., Ramaekers, F. et al. In situ hybridization: A possible diagnostic aid in leptomeningeal metastasis. J Neurooncol 38, 127–133 (1998). https://doi.org/10.1023/A:1005926624303

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