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Synthesis and Biological Properties of 3-(Dihydroxybenzoyloxy)methyl- and 3-(Diacetoxybenzoyloxy)methyl-7α-chlorocephalosporanate Sulfones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

We describe the synthesis of tert-butyl esters of 3-(2-hydroxybenzoyloxy)methyl-, 3-(dihydroxybenzoyloxy)methyl-, and 3-(diacetoxybenzoyloxy)methyl-7α-chlorocephalosporanic acid sulfones by reaction of tert-butyl ester of 3-bromomethyl-7α-chlorocephalosporanic acid sulfone with salts of hydroxy- and acetoxy-substituted benzoic acids. We have investigated the elastase-inhibiting properties of the compounds obtained and also their in vitro cytotoxic activity.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, Riga, LV-1006; veinberg@osi.lv

    N. Grigan, G. Veinberg, I. Shestakova, I. Kanepe & E. Lukevics

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  1. N. Grigan
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  2. G. Veinberg
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  3. I. Shestakova
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  4. I. Kanepe
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  5. E. Lukevics
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Grigan, N., Veinberg, G., Shestakova, I. et al. Synthesis and Biological Properties of 3-(Dihydroxybenzoyloxy)methyl- and 3-(Diacetoxybenzoyloxy)methyl-7α-chlorocephalosporanate Sulfones. Chemistry of Heterocyclic Compounds 36, 1232–1236 (2000). https://doi.org/10.1023/A:1002885103646

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  • DOI: https://doi.org/10.1023/A:1002885103646

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