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Current Approaches to Novel Therapeutics in Pancreatic Cancer

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Abstract

Pancreatic cancer is one of the most refractory neoplasms to medical treatment. Until now there has been only modest improvement in the treatment of this disease. Standards of care for combined-modality treatment of resectable as well as locally advanced, unresectable disease have not been uniformly accepted to date because of an equivocal or conflicting data. The inception of gemcitabine introduced the new era in the management of metastatic pancreatic cancer, however, new therapeutic approaches still need to be defined. The article discusses the current knowledge of the biology of this lethal disease, its impact on treatment options, and explores novel therapeutic modalities that are likely to improve outcomes and survival for patients in the future.

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Authors and Affiliations

  1. Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York, USA

    Corina E. Akerele, Irina Rybalova & Sridhar Mani

  2. Herbert Irving Cancer Center, Columbia Presbyterian Medical Center, New York, NY, USA

    Howard L. Kaufman

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  1. Corina E. Akerele
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Akerele, C.E., Rybalova, I., Kaufman, H.L. et al. Current Approaches to Novel Therapeutics in Pancreatic Cancer. Invest New Drugs 21, 113–129 (2003). https://doi.org/10.1023/A:1022936914328

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