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Use of Mathematical Modeling for Estimation of the Toxic Action of Some Medical Agents

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Abstract

A mathematical model of a granulocytic series of blood formation (hemopoiesis) is set out, with the aid of which it is possible to solve effectively the problem involved with the determination of the sensitivity of cells of the bone marrow to the toxic action of cytostatic agents that are widely used in medicine, in particular, for the cure of oncologic diseases. The results of numerical model experiments on a computer make it possible to analyze an unlimited number of versions describing various situations of the lesion of cells of the bone marrow in the framework of the presented model and trace the dynamics of recovery of the hemopoietic system after the injection of agents with a different mechanism of the toxic effect.

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  1. Trapeznikov Institute of Control Sciences, Russian Academy of Sciences, Moscow, Russia

    N. A. Babushkina

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  1. N. A. Babushkina
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Babushkina, N.A. Use of Mathematical Modeling for Estimation of the Toxic Action of Some Medical Agents. Automation and Remote Control 63, 111–124 (2002). https://doi.org/10.1023/A:1013791521193

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