The potential interaction between oral anticoagulants and acetaminophen in everyday practice
- 78 Downloads
Objective: The drug–drug interaction between oral anticoagulants (especially warfarin) and acetaminophen has been described, but evidence is conflicting and evidence for a similar interaction between acenocoumarol or phenprocoumon and acetaminophen is limited. Therefore, a study was performed to determine the influence of acetaminophen on oral anticoagulation with acenocoumarol or phenprocoumon in everyday practice.Method: Included were patients from two Dutch anticoagulant clinics who had used oral anticoagulants for at least three months and who started with acetaminophen (case group) or benzodiazepines (control group). Results: Fifty-four patients were included who had a first prescription of acetaminophen in their pharmacy record (during oral anticoagulant use) and twenty patients with a first prescription of a benzodiazepine (during oral anticoagulant use). The INR (International Normalized Ratio) difference before and after acetaminophen use was not statistically significant between the two groups and showed no dose dependency.Conclusion: These data do not demonstrate that acetaminophen, in the dosages used in everyday practice, has a clinically relevant influence on the INR in patients using acenocoumarol or phenprocoumon
Unable to display preview. Download preview PDF.
- 4.Chan TYK. Interactions of acetaminophen, opiates, and their combinations with warfarin and other oral anticoagulants. J Pharm Technol 1997;13:89–92.Google Scholar
- 6.Johnsen SP, Sorensen HT, Mellemkjoer L, Blot WJ, Nielsen GL, McLaughlin JK et al. Hospitalisation for upper gastrointestinal bleeding associated with use of oral anticoagulants. Throm Haemost 2001;86:563–8.Google Scholar
- 10.Van Loenen AC, editor Farmacotherapeutisch kompas, 18th ed. Amstelveen: College voor Zorgverzekeringen, 2002:244–6.Google Scholar