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Pharmacy World and Science

, Volume 24, Issue 3, pp 111–116 | Cite as

Evaluation of human albumin use in a university hospital in Belgium

  • A. Somers
  • T. Bauters
  • H. Robays
  • M. Bogaert
  • F. Colardyn
Article

Abstract

In 1996 — 1997, a drug use evaluation )DUE) of human albumin was conducted in the Ghent University Hospital )Belgium) to determine the pattern and appropriateness of the albumin use. The DUE was followed by permanent review of the albumin consumption. This paper describes how the DUE was carried out and how the albumin use in our hospital changed over time.Method: The study was based on criteria for indications and end of treatment, accepted by consensus of the physicians prescribing albumin. Albumin treatment episodes were classified as appropriate or inappropriate according to these criteria.Results: For 115 treatment episodes in 90 patients, the researchers found 21 )18.3%) deviations from the developed criteria. After analysis, half out of them were considered as minor. Most deviations involved starting treatment too early )n = 17). Follow-up results indicated that the overall consumption of albumin dropped by 50.1% from 1994 to 1999, while the consumption of colloid solutions during the same period remained stable.Conclusion: A good compliance with internally developed criteria for indications and end of treatment with human albumin was observed. Discussion with the clinicians involved led to the development of stricter criteria and a continuous decrease in albumin consumption.

Belgium Colloids Criteria Drug administration Drug use evaluation (DUE) Drug utilization review (DUR) Human albumin Total Quality Assurance (TQA) 

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References

  1. 1.
    Bowman I. Drug Use Evaluation is DUE: healthcare utilization evaluation is over-DUE. Hospital Pharmacy 1996;3:5–8.Google Scholar
  2. 2.
    Sacristan J, Soto J. Drug utilisation studies as tools in health economics. Pharmaco-economics 1994;5(4):299–312.Google Scholar
  3. 3.
    Laffel G, Berwick DM. Quality in Healthcare. JAMA 1996;268:407–9.Google Scholar
  4. 4.
    Missan G, Alderman C, Brown E, Burgess N, Coutlhard K, Demos L, Dollman C et al. SHPA Standards of practice for drug usage evaluation in Australian hospitals. Australian Journal Hospital Pharmacy 1996;26:240–7.Google Scholar
  5. 5.
    ASHP. ASHP guidelines on medication-use evaluation. Am J Health-Syst Pharm 1996;53:1953–5.Google Scholar
  6. 6.
    Lepaux DJ, Bignolas G, Demange C, Dufay E, Conzalvez MF, Juste M. Pourquoi et comment evaluer la qualité de la prescription du médicament? Pharmacie Hospitalière 1994;29(118):27–32.Google Scholar
  7. 7.
    Doweiko JP, Nompleggi DJ. Use of albumin as a volume expander. Journal Enteral Parenteral Nutrition 1991;15:484–7.Google Scholar
  8. 8.
    Richardson NGB, O'Shaughnessy D. Use of albumin. BMJ 1995;311:129Google Scholar
  9. 9.
    Ministerie van Volksgezondheid, Hoge Gezondheidsraad en Geneesmiddelencommissie. Perfusie van menselijke albumine en vervangoplossingen (April 1994).Google Scholar
  10. 10.
    Ferrier L, Torner P, Verry A. Connaissance des indications et des motifs de prescription des albumines au Centre Hospitalier de Sens. Le Pharmacien Hospitalier 1996;31 (126):15–23.Google Scholar
  11. 11.
    Wisniewski S, Woronoff Lemsi MC, Neidhart M. Albumine et solutions de remplissage au Centre Hospitalier Universitaire de Besançon. Le Pharmacien Hospitalier 1995;30 (120):17–24.Google Scholar
  12. 12.
    Debrix I, Combeau D et al. Clinical practice gduielines for the use of albumin: results of a drug use evaluation in a Paris hospital. Pharm World Sci 1999;21(1):11–6Google Scholar
  13. 13.
    Natsch S, van Leeuwen SJ et al. Use of albumin in intensive care unit patients-is continuous quality assessment necessary? J Clin Pharm Ther 1998;23:179–83.Google Scholar
  14. 14.
    Société francaise d'Anesthésie et de Réanimation. L'utilisation de l'albumine en Anesthésie Réanimation chirurgicale chez l'adulte. Conférence de Consensus du 15 décembre 1995.Google Scholar
  15. 15.
    Golub R, Sorrento J, Cantu R et al. Efficacy of albumin supplementation in the surgical intensive care unit: a prospective, randomised study. Crit Care Med 1994;22:613–9.Google Scholar
  16. 16.
    Rubin H, Carlson S, DeMeo M et al. Randomized, doubleblind study of intravenous human albumin in hypoalbuminaemic patients receiving total parenteral nutrition. Crit Care Med 1997;25:249–52.Google Scholar
  17. 17.
    Wickstrom G et al. The “Hawthorne effect”-what did the original Hawthorne studies actually show? Scand J Work Environ Health 2000;26(4):363–7Google Scholar
  18. 18.
    Cochrane Injuries Group Albumin Reviewers. Human albumin administration in cirtically ill patients: systematic review of randomised controlled trials. BMJ 1998;317:235–40Google Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • A. Somers
    • 1
  • T. Bauters
    • 1
  • H. Robays
    • 1
  • M. Bogaert
    • 2
  • F. Colardyn
    • 3
  1. 1.Hospital PharmacyGhent University HospitalBelgium
  2. 2.Heymans Institute of PharmacologyGhent UniversityBelgium
  3. 3.Intensive Care DepartmentGhent University HospitalBelgium

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