Advertisement

Journal of Radioanalytical and Nuclear Chemistry

, Volume 249, Issue 2, pp 443–447 | Cite as

Use of bomb pulse 14C to age senile plaques and neurofibrillary tangles in the Alzheimer's disease brain

  • J. D. RobertsonEmail author
  • M. A. Lovell
  • B. Buchholz
  • Chengsong Xie
  • W. R. Markesbery
Article
  • 45 Downloads

Abstract

The time course and defining factors involved in the formation of neurofibrillarytangles (NFT) and senile plaques (SP) in Alzheimer's disease (AD) brainare unknown. Above ground nuclear weapons tests led to significantly increasedlevels of 14C in the carbon cycle. Because SP and NFT are relativelyresistant to degradation, the 14C levels in SP and NFT should reflecttheir year of formation. Through the use of accelerator mass spectrometry(AMS) and the measurement of 14C levels, we have determined theaverage age of formation of isolated SP and NFT fractions of 6 AD subjects.While a heterogeneous process of formation is indicated, NFT pre-date SP inthe majority of cases. In addition, it is clear that NFT and SP have a muchslower carbon turnover rate than normal brain tissue.

Keywords

Brain Tissue Turnover Rate Normal Brain Carbon Cycle Neurofibrillary Tangle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    R. Katzman, Arch. Neurol., 33 (1976) 217.CrossRefGoogle Scholar
  2. 2.
    D. A. Evans et al., JAMA, 262 (1989) 2251.CrossRefGoogle Scholar
  3. 3.
    National Institute on Aging. Progress Report on Alzheimer's Disease. NIH Publications # 95–3994, Washington, DC, US Government Printing Office, 1995.Google Scholar
  4. 4.
    G. D. McKhann et al., Neurology, 34 (1984) 939.CrossRefGoogle Scholar
  5. 5.
    B. C. Jost,G. T. Grossberg, J. Am. Ger. Soc., 43 (1995) 1248.CrossRefGoogle Scholar
  6. 6.
    W. R. Markesbery, Free Rad. Biol. Med., 23 (1997) 134.CrossRefGoogle Scholar
  7. 7.
    D. J. Selkoe,P. J. Lansbury, Basic Neurochemistry: Molecular, Cellular and Medical Apsects, G. J. Siegel,B. W. Agravoff,R. G. Albers,S. K. Fisher andM. D. Uhler (Eds), 6th ed., 1999, p. 950.Google Scholar
  8. 8.
    A. Delacourte et al., Neurology, 52 (1999) 1158.CrossRefGoogle Scholar
  9. 9.
    J. L. Price,J. C. Morris, Ann. Neurol., 45 (1999) 358.CrossRefGoogle Scholar
  10. 10.
    H. Braak,E. Braak, Neurobiol. Aging, 18 (1997) 351.CrossRefGoogle Scholar
  11. 11.
    T. G. Ohm,H. Muller,H. Braak,J. Bohl, Neuroscience, 64 (1995) 209.CrossRefGoogle Scholar
  12. 12.
    M. Roth,B. E. Tomlinson,G. Blessed, Nature, 209 (1966) 109.CrossRefGoogle Scholar
  13. 13.
    P. Delaere et al., Acta Neuropathol., 77 (1989) 645.CrossRefGoogle Scholar
  14. 14.
    D. G. Davis et al., J. Neuropathol. Exp. Neurol., 58 (1999) 376.CrossRefGoogle Scholar
  15. 15.
    G. K. Wilcock,M. M. Esiri, J. Neurol. Sci., 56 (1982) 343.CrossRefGoogle Scholar
  16. 16.
    L. M. Bierer et al., Arch. Neurol., 52 (1995) 81.CrossRefGoogle Scholar
  17. 17.
    D. W. Dickson et al., Neurobiol. Aging, 16 (1995) 285.CrossRefGoogle Scholar
  18. 18.
    M. Morimatsu,S. Hirai,A. Muramatsu,M. Yoshikawa, J. Am. Geriatr. Soc., 23 (1975) 390.CrossRefGoogle Scholar
  19. 19.
    D. Neary et al., J. Neurol. Neurosurg. Psychiatry, 49 (1986) 229.CrossRefGoogle Scholar
  20. 20.
    J. C. Morris et al., Neurology, 41 (1991) 469.CrossRefGoogle Scholar
  21. 21.
    M. Bobinski et al., J. Neuropathol. Exp. Neurol., 56 (1997) 414.CrossRefGoogle Scholar
  22. 22.
    M. Bobinski et al., Brain Res., 799 (1998) 156.CrossRefGoogle Scholar
  23. 23.
    R. Morsch,W. Simon,P. D. Coleman, J. Neuropathol. Exp. Neurol., 58 (1999) 188.CrossRefGoogle Scholar
  24. 24.
    M. J. Stenhouse,M. S. Baxter, Nature, 267 (1977) 828.CrossRefGoogle Scholar
  25. 25.
    E. M. Drueffel,H. Y. I. Mok, Radiocarbon, 25 (1983) 629.CrossRefGoogle Scholar
  26. 26.
    W. S. Broecker,A. Schulert,E. A. Olson, Science, 130 (1959) 331.CrossRefGoogle Scholar
  27. 27.
    D. D. Harkness,A. Walton, Nature, 240 (1972) 302.CrossRefGoogle Scholar
  28. 28.
    G. McKhann et al., Neurology, 34 (1984) 939.CrossRefGoogle Scholar
  29. 29.
    National Institute on Aging, and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer' Disease, Neurobiol. Aging, 18 (1997) S1.CrossRefGoogle Scholar
  30. 30.
    P. D. Gorevic et al., J. Neuropathol. Exp. Neurol., 45 (1986) 647.CrossRefGoogle Scholar
  31. 31.
    J. S. Vogel,J. R. Southon,D. E. Nelson, Nucl. Instr. Meth. Phys. Res., B 29 (1987) 50.CrossRefGoogle Scholar
  32. 32.
    M. Stuiver,H. A. Polach, Radiocarbon, 19 (1977) 355.CrossRefGoogle Scholar
  33. 33.
    S. G. Greenberg,P. Davies, Proc. Natl. Acad. Sci. USA, 87 (1990) 5827.CrossRefGoogle Scholar
  34. 34.
    D. J. Selkoe,C. R. Abraham,M. B. Podlisny,L. K. Duffy, J. Neurochem., 46 (1986) 1820.CrossRefGoogle Scholar
  35. 35.
    R. Morsch,W. Simon,P. D. Coleman, J. Neuropathol. Exp. Neurol., 58 (1999) 188.CrossRefGoogle Scholar
  36. 36.
    E. M. Druffel,H. Y. I. Mok, Radiocarbon, 25 (1983) 629.CrossRefGoogle Scholar
  37. 37.
    R. Nydal,K. Lovseth, J. Geophys. Res., 88 (1983) 2621.CrossRefGoogle Scholar
  38. 38.
    I. Levin et al., Radiocarbon, 27 (1985) 1.CrossRefGoogle Scholar
  39. 39.
    http://cdiac.esd.ornl.gov/trends/co2/contents.htmGoogle Scholar
  40. 40.
    http://cdiac.esd.ornl.gov/epubs/ndp/ndp057/ndp057.htmGoogle Scholar

Copyright information

© Kluwer Academic Publishers/Akadémiai Kiadó 2001

Authors and Affiliations

  • J. D. Robertson
    • 1
    Email author
  • M. A. Lovell
    • 2
    • 3
  • B. Buchholz
    • 4
  • Chengsong Xie
    • 2
  • W. R. Markesbery
    • 2
    • 5
  1. 1.Department of ChemistryUniversity of MissouriColumbia, MOUSA
  2. 2.Sanders-Brown Center on AgingUniversity of KentuckyLexington, KYUSA
  3. 3.Department of ChemistryUniversity of KentuckyLexington, KYUSA
  4. 4.Lawrence Livermore National LaboratoryLivermore, CAUSA
  5. 5.Departments of Neurology and PathologyUniversity of KentuckyLexingtonUSA

Personalised recommendations