Feasibility study for the production of 32 P-labeled diphosphonic acids by neutron irradiation and radiochemical separation
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Two simple diphosphonates, CH6P2 O6(MDP) and C2 H8 P2 O7 (HEDP),have been irradiated with neutrons to produce the corresponding 32P-labeled compounds. After irradiation for 0.5–5 hours in a thermalneutron flux of 4.2 . 1016 n . m —2 s—1 the irradiated compounds were dissolved and fractionated using a SephadexG10 column. The separated fractions were identified using planar paper chromatographyand autoradiography. The labeling yield was ca 35% for each of the compounds,and the specific activity attainable ranged up to 4.8 GBq . mol —1 . For practical applications, the labeled diphosphonates have to bepurified further.
KeywordsPhysical Chemistry Inorganic Chemistry Feasibility Study Neutron Irradiation Diphosphonates
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