Journal of Radioanalytical and Nuclear Chemistry

, Volume 249, Issue 2, pp 437–441 | Cite as

Differences in trace element concentrations between Alzheimer and “normal” human brain tissue using instrumental neutron activation analysis (INAA)

  • A. E. Panayi
  • N. M. SpyrouEmail author
  • P. Part


Brain samples obtained from the Netherlands Brain Bank were taken fromthe superior frontal gyrus, superior parietal gyrus and medial temporal gyrusof 'normal' and Alzheimer's disease subjects in order todetermine elemental concentrations and compare elemental composition. Brainsamples from the cortex were taken from 18 subjects, eight 'normals'(6 males and 2 females) and eleven with Alzheimer's disease, (1 maleand 10 females) and the following elemental concentrations, Na, K, Fe, Zn,Se, Br, Rb, Ag, Cs, Ba, and Eu were determined by instrumental neutron activationanalysis (INAA). The element which showed the greatest difference was Br,which was found to be significantly elevated in the cortex of Alzheimer'sdisease brains as compared to the 'normals' at significance (p<0.001).


Physical Chemistry Inorganic Chemistry Brain Tissue Human Brain Elemental Composition 
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Copyright information

© Kluwer Academic Publishers/Akadémiai Kiadó 2001

Authors and Affiliations

  1. 1.Physics DepartmentUniversity of SurreyGuildfordUK
  2. 2.Environmental ImpactJRCIspraItaly

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