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Pharmacy World and Science

, Volume 23, Issue 5, pp 179–180 | Cite as

Gentamicin dosing in neonatal patients

  • N. Gooding
  • A. Elias‐Jones
  • M. Shenoy
Article

Abstract

Objective: To compare trough and peak serum gentamicin concentrations in neonatal patients using two dosing regimens.

Method: A retrospective audit of gentamicin serum concentrations obtained with the current neonatal gentamicin‐dosing regimen (regimen 1) was conducted. Results were then compared with the introduction of a new regimen (regimen 2). Preliminary results necessitated a change to a further dosage schedule (regimen 3), where data was again collected.

Results: For regimen 1,79% of patients achieved satisfactory trough concentrations, 30% achieved satisfactory peak concentrations, and 16% achieved a satisfactory combined trough and peak concentration.For regimen 2,80% of patients achieved satisfactory trough concentrations, 63% achieved satisfactory peak concentrations, and 48% achieved a satisfactory combined trough and peak concentration.For regimen 3,76% of patients achieved satisfactory trough concentrations, 56% achieved satisfactory peak concentrations, and 45% achieved a satisfactory combined trough and peak concentration.

Conclusion: Regimen 3 shows a marked improvement in serum gentamicin concentrations. However neonates in the 32‐38 weeks post‐conceptional age group achieved higher trough and peak serum gentamicin levels than expected. Therefore the dosage interval in this group of neonates will be increased from 18 hourly to 24 hourly dosing, and regimen reaudited.

Dose calculation Gentamicin 

References

  1. 1.
    McCormack JP, Jewesson PJ. A critical re-evaluation of the 'therapeutic range' of aminoglycosides. Clin Infect Dis 1992;14:320-39.Google Scholar
  2. 2.
    Thomson AH, Way S, Bryson SM, McGovern EM, Kelmann AW. Population pharmacokinetics of gentamicin in neonates. Dev Pharmacol Ther 1988;11:173-9Google Scholar
  3. 3.
    Moore RD, Smith CR, Lietman PS. The association of aminoglycoside plasma levels with mortality in patients with Gram negative bacteremia. J Infect Dis 1984;149:443-8Google Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • N. Gooding
    • 1
  • A. Elias‐Jones
    • 2
  • M. Shenoy
    • 3
  1. 1.Dept. of PharmacyLeicester Royal InfirmaryLeicesterEngland, UK
  2. 2.Leicester Royal Infirmary and Neonatal UnitLeicester General HospitalLeicesterUK
  3. 3.Neonatal UnitLeicester General HospitalLeicesterUK

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