Pharmacy World and Science

, Volume 21, Issue 1, pp 11–16 | Cite as

Clinical practice guidelines for the use of albumin: result of a drug use evaluation in a Paris Hospital

  • I. Debrix
  • D. Combeau
  • F. Stephan
  • A. Becker


Chromatographic analysis of bisphosphonates in the past has been based primarily on reversed‐phase liquid chromatography (RPLC) and ion‐exchange chromatography. Gas chromatography (GC) and recently even capillary electrophoresis have also been employed. For bioanalysis, pre‐treatment of the sample is a major part of the analysis; protein precipitation, calcium precipitation, solid‐phase extraction (SPE) and derivatization have demonstrated to play an important role in bisphosphonate assays. For some of these treatments, for example SPE and derivatization, automation may be possible. Derivatization is a prerequisite for GC analysis of bisphosphonates; a volatile derivative has to be formed. For liquid chromatography, two types of derivatization are known for bisphosphonates. First, the bisphosphonate side chain can be modified by a chemical reaction to yield a derivative with advantageous chromatographic and spectroscopic properties. Secondly, by complexation of both phosphonate groups or of phosphate after decomposition of the analyte, a coloured complex can be formed. The most sensitive bioanalytical methods are based on RPLC and fluorescence detection, if necessary after derivatization. If low detection limits are not required, for example for analysis of pharmaceutical preparations, non-specific detection methods can be applied.

Albumin Clinical practice guidelines Daily patient specific decision support Drug use evaluation 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Elson RB. Clinical practice guidelines. Dis Manage Health Outcomes 1997;1, 2:63-74.Google Scholar
  2. 2.
    Agence Nationale pour le developpement de l'évaluation médicale. Les recommandations de pratique clinique: guide pour leur élaboration. Paris: ANDEM 1993:72.Google Scholar
  3. 3.
    Bosquet P, Goldberg J, Matillon Y. Comment élaborer des recommandations de pratique clinique? Bull Cancer 1995;82:754-60.PubMedGoogle Scholar
  4. 4.
    Société de réanimation de langue française. 4 ème conférence de consensus en médecine d'urgence: choix des produits de remplissage vasculaire pour le traitement des hypovolémies. Réan Soins Med Urg 1989;5:295-336.Google Scholar
  5. 5.
    Société Française d'anesthesie et de réanimation. Conférence de consensus sur l'utilisation des solutions d'albumine humaine en anesthésie-réanimation chirurgicale chez l'adulte. ANDEM, 1995.Google Scholar
  6. 6.
    Vermelen LC, Rakto TA, Erstad BL, Brecher ME, Matuszewski KA. A paradigm for consensus: the university hospital consortium guidelines for the use of albumin, non protein colloid and cristalloid solutions. Arch Intern Med 1995;155:373-9.Google Scholar
  7. 7.
    Grimshaw JM, Russel IT. Effect of clinical guidelines on medical practice: a systematic review of rigorous evaluations. Lancet 1993;342:1317-22.PubMedGoogle Scholar
  8. 8.
    Gold MS, Russo J, Tissot M, Weinhouse G, Riles T. Comparison of hetastarsch to albumin for perioperative bleeding in patients undergoing abdominal aortic aneurysm surgery. Ann Surg 1990;211:482-85.PubMedGoogle Scholar
  9. 9.
    Golub R, Sorrento JJ, Cantu R, Nierman DM, Moideen A, Stein HD. Efficacy of albumin supplementation in the surgical intensive care unit: a prospective randomized study. Crit Care Med 1994;22:613-9.PubMedGoogle Scholar
  10. 10.
    Stockwell MA, Soni N, Riley B. Colloid solutions in the critically ill. A randomized comparison of albumin and polygelin. Outcome and duration of stay in the intensive care unit. Anesthesia 1992;47:3-6.Google Scholar
  11. 11.
    Audibert G, Donner M, Lefevre JC, Stoltz JF, Laxenaire MC. Rheologic effects of plasma substitutes used for preoperative hemodilution. Anesth Analg 1994;78:740-5.PubMedGoogle Scholar
  12. 12.
    Mathru M, Rao TLK, kartha RK, Shanmugham M, Jacobs HK. Intravenous albumin for prevention of spinal hypotension for cesarian section. Anesth Analg 1980;59:655-8.PubMedGoogle Scholar
  13. 13.
    Gibbs CP, Spohr L, Petrakis J, Paulus D, Schultetus R. Prevention of hypotension with hydratation. Anesthesiology 1981;55:308.Google Scholar
  14. 14.
    Gines A, Fernandez-Gloria G, Monescillo A, et al. Randomized trial comparing Albumin, Dextran 70, and Polygeline in cirrhotic patients with ascities treated by paracentesis. Gastroenetrol 1996;11:1002-10.Google Scholar
  15. 15.
    Bernard B, Moreau R, Lebrec D, Opolon P, Poynard T. Albumin vs synthetic plasma expanders in cirrhotic patients with ascities treated by paracentesis: a meta-analysis. Hepatology 1997;26, n°4: 2.Google Scholar
  16. 16.
    Shoham Z, Weissman A, Barash A, Borenstein R, Schachter M, Insler V. Intravenous albumin for the prevention of severe ovarian hyperstimulation syndrome in an in vitro fertilization program: a prospective, randomized, placebo controlled study. Fertil Steril 1994;62:137-42.PubMedGoogle Scholar
  17. 17.
    Stockwell MA, Scott A, Day A, Riley B, Soni N. Colloid solution in the critically ill. A randomized comparison of albumin and polygeline. Anesthesia 1992;47:7-9.Google Scholar
  18. 18.
    Foley EF, Borlase BC, Dzik WH, Bistrian, Benotti PN. Albumin supplementation in the critically ill. Arch Surg 1990;125:739-42.PubMedGoogle Scholar
  19. 19.
    Rackow EC, Mecher C, Astiz ME, Griffel M, Falk JL, Weil MH. Effects of pentastarsh and albumin infusion on cardiorespiratory function and coagulation in patients with severe sepsis and systemic hypoperfusion. Crit Care Med 1989;17:394-8.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • I. Debrix
  • D. Combeau
  • F. Stephan
  • A. Becker

There are no affiliations available

Personalised recommendations