Pharmacy World and Science

, Volume 19, Issue 5, pp 251–252 | Cite as

Calcium dobesilate-induced agranulocytosis.

  • Elena García Benayas
  • Benito García Díaz
  • Guillermo Pérez


Here we report a case of a patient in whom the administration of calcium dobesilate was associated with the development of an agranulocytosis episode. Eight weeks after the beginning of the treatment he was hospitalized with fever and leucopenia. Bone marrow biopsy showed a maturative promyelocytic interruption. All medication was withdrawn and blood cell count was completely recovered 7 days after admission. G‐CSF was administered. A detailed study was performed and causal relationship was not suggestive for the other three drugs the patient was receiving. To date, there have only been reported two cases of calcium dobesilate induced agranulocytosis.

Adverse reaction Agranulocytosis Calcium dobesilate Neutropenia 


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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Elena García Benayas
    • 1
  • Benito García Díaz
    • 1
  • Guillermo Pérez
    • 1
  1. 1.Severo Ochoa HospitalMadridSpain

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