Abstract
The cyclic transmission of African trypanosomes is subject to the successful passage through successive ‘biological barriers’ associated with the ecology and physiology of the host(s) and vector(s), and the ability of the parasite to adjust to the various substrates. This paper is an analytical compilation of factors which play a relevant role in the complex pathway characteristic of trypanosome transmission. These are discussed under the following headings: (a) physiology of the parasite; (b) physiology of the vector; (c) ecology of the vector; (d) feeding habits of the vector; (e) physiology of the vertebrate host; and (f) behaviour of the vertebrate host.
Similar content being viewed by others
References
Allsop R., Baldry D. A. T. and Rodrigues C. (1972) The influence of game animals on the distribution and feeding habits of Glossina pallidipes in the Lambwe Valley. Bull. Wld. Hlth. Org. 47, 795–809.
Amreim Y. U., Geighy R and Kaufmann M. (1965) On the reacquisition of virulence in trypanosomes of the brucei group. Acta trop. 22, 193–203.
Ashcroft M. T. (1959) The importance of African wild animals as reservoirs of trypanosomiasis. E. Afri. Med. J. 36, 247–161.
Ashcroft M. T., Burt E. and Fairbairn H. (1959) The experimental infection of some African wild animals with T. rhodesiense, T. brucei and T. congolense. Ann. trop. Med. Parasit. 53, 137–146.
Baker J. R. (1968) Trypanosomes of wild animals in the neighbourhood of the Serengeti National Park. Symp. Zool. Soc. Lond. 24, 147–158.
Baker J. R., Sachs R. and Laufer I. (1967) Trypanosomes of wild animals in an area northwest of the Serengeti National Park. Z. Tropenmed. Parasit. 18, 280–284.
Burtt E. (1946) Incubation of tsetse pupae: increased transmission rate of Trypanosoma rhodesiense in Glossina morsitans. Ann. trop. Med. Parasit. 40, 18–28.
Buxton P. A. (1955) The Natural History of Tsetse Flies. Mem. London Sch. Hyg. & Trop. Med., No. 10.
Challier A., Eyraud M., Lafaye A. and Laveissiere (1977) Amélioration du rendement de piège bicon-ique pour Glossines par l’emploi d’un cône inférieur bleu. Cah. O.R.S.T.O.M., sér. ent. med. parasit. XV, 282–286.
Clarke J. E. (1965) Trypanosomes infections in the mouth-parts of Glossina morsitans: a correlation between the extent of labral infection and invasion of the hypopharynx. Ann. trop. Med. Parasit. 59, 235–239.
Clarke J. E. (1966) Trypanosome infections in the mouth-part of Glossina morsitans: variation in frequency and extent of labral infections with age. Ann. trop. Med. Parasit. 60, 223–229.
Clarke J. E. (1970) Trypanosome infection rates in the mouthparts of Zambian tsetse flies. Ann. trop. Med. Parasit. 64, 164–165.
Cunningham M. P. and Vickerman K. (1962) Antigenic analyses of the Trypanosome brucei group, using the agglutination reaction. Trans. R. Soc. trop. Med. Hyg. 56, 48–59.
Damian R. T. (1964) Molecular mimicry: antigen sharing by parasite and host and its consequences. Am. Naturalist 98, 129–149.
De Andrea Silva M. A. and Marques Da Silva J. (1958) On the incidence of Trypanosomiasis in game. C.S.I.T.R., 7th Meeting, 269–272.
Desowitz R. and Watson H. J. C. (1953) Studies on Trypanosoma vivax. Iv. The maintenance of a strain in white rats without sheepserum supplement. Ann. trop. Med. Parasit. 47, 62–67.
Dodin A. and Fromentin H. (1962) Mise en évidence d’un antigène vaccinant dans le plasme de souris expérimentalement infectées par Trypanosoma gambiense et par T. congolense. Bull. Soc. Path. exot. 55, 128–138.
Erickson I. C. and Møller A. R. (1975) Tsetse fly Glossina morsitans morsitans produces ultrasound related to behaviour. Experimentia 31, 788–790.
Fairbairn H. and Burtt E. (1946) The infectivity to man of a strain of Trypanosoma rhodesience transmitted cyclically by Glossina morsitans through sheep and antelope: evidence that man requires a minimum infective dose of metacyclic trypanosomes. Ann. trop. Med. Parasit. 40, 270–313.
Fairbairn H. and Culwick A. T. (1950) The transmission of polymorphic trypanosomes. Acta trop. 7, 19–47.
Ford J. and Leggate B. M. (1961) The geographical and climatic distribution of trypanosome infection rates in Glossina morsitans group of flies. Trans. R. Soc. trop. Med. Hyg. 55, 383–397.
Frezil J. L. (1971) Application du xénodiagnostic dans le dépistage de la trypanosomiase a T. gambiense chez des sujets immunologiquement suspect. Bull. Soc. Path. Exot. 64, 871–878.
Frezil J. L. and Carnevale P. (1976) Utilisation de la carboglace pour la capture de Glossina fuscipes quan-zensis avec le piège Challier-Laveissière. Conséquences épidémiologiques. Cah. O.R.S.T.O.M., ser. Ent. méd. parasit. XIV, 225–233.
Galun R. (1975) The role of host-blood in the feeding behaviour of ectoparasites. In Dynamic Aspects of Host-Parasite Relationship, Vol. II (Ed. by Zuckerman A.), John Wiley, New York.
Geigy R., Kauffmann M. and Beglinger R. (1967) A survey of wild animals as potential reservoirs of trypanosomiasis in the U langa District (Tanzania). Acta trop. 24, 97–108.
Geigy R. and Kauffmann M. (1973) Sleeping sickness survey in the Serengeti area (Tanzania) 1971. I. Examination of large mammals for trypanosomes. Acta. trop. 30, 12–23.
Geigy R. M., Kauffmann M., Mayende J. S. P., Mwambu P. M. and Onyango R. J. (1973) Isolation of Trypanosoma rhodesiense from game and domestic animals in Musoma District, Tanzania. Acta. trop. 30, 49–56.
Glasgow J. P. (1961) The feeding habits of Glossina swynnertoni. J. Anim. Ecol. 30, 77–85.
Glasgow J. P. and Wilson F. (1953) A census of the tsetse fly Glossina pallidipes Austen and of its host animals. J. Anim. Ecol. 22, 47–56.
Glasgow J. P., Isherwood F., Lee-Jones F. and Weitz B. (1958) Factors influencing the staple food of tsetse. J. Ann. Ecol. 27, 59–69.
Godfrey D. G. (1961) Types of Trypanosoma congolense. II. Differences in the course of infection. Ann. trop. Med. Parasit. 55, 154.
Gray A. R. (1965) Antigenic variations in a strain of Trypanosoma brucei transmitted by Glossina morsitans and G. palpalis. J. gen. Microbiol. 41, 195–214.
Gray A. R. (1975) A pattern in the development of agglutino-genic antigens of cyclically transmitted isolates of Trypanosoma gambiense. Trans. R. Soc. trop. Med. Hyg. 69, 131–138.
Harley J. M. B. (1971) Comparison of the susceptibility to infection with Trypanosoma rhodesiense of Glossina pallidipes, G. fuscipes and G. brevipalpis. Ann. trop. Med. Parasit. 65, 191–196.
Harley J. M. B., Cunningham M. P. and Van Hoeve K. (1966) The numbers of infective Trypanosoma rhodesiense extruded by Glossina morsitans during feeding. Ann. trop. Med. Parasit. 60, 455–460.
Harley J. M. B. and Wilson A. J. (1968) Comparison between Glossina morsitans, G. pallidipes and G. fuscipes as vectors of trypanosomes of the Trypanosoma congolense group; the proportions infected experimentally and the numbers of infective organisms extruded during feeding. Ann. trop. Med. Parasit. 62, 178–187.
Harmsen R. (1973) The nature of the establishment barrier for Trypanosoma brucei in the gut of Glossina pallidipes. Trans. R. Soc. trop. Med. hyg. 67, 364–373.
Isherwood F., Duffy B. J., Glasgow J. P., Lee-Jones F. and Weitz B. (1961) Further studies of the food of tsetse flies. J. Anim. Ecol. 30, 259–266.
Janssen J. A. H. A. and Wijers D. J. B. (1974) Trypanosoma simiae at the Kenya coast. A correlation between virulence and the transmitting species of Glossina. Ann. trop. Med. Parasit. 68, 5–19.
Jordan A. M. (1964) Trypanosome infection rate in Glossina morsitans submorsitans in northern Nigeria. Bull. ent. Res. 55, 219–231.
Jordan A. M. (1965) The host of Glossina as the main factor affecting trypanosome infection rates of tsetse flies in Nigeria. Tvvrans. R. Soc. trop. Med. Hyg. 59, 423–431.
Kolbe F. E. (1973) The modulated sounds made by the tsetse fly Glossina brevipalpis. Zoo. Afr. 8, 241–258.
Lambrecht F. L. (1964) Aspects of evolution and ecology of tsetse flies and trypanosomasis in prehistoric African environment. J. Afr. Hist. 5, 1–24.
Lambrecht F. L. (1965) Biological variations in trypanosomes and their relation to the epidemiology of Chagas’ disease. Rev. Inst. Med. trop. Sao Paulo 7, 346–352.
Lambrecht F. L. (1967) Trypanosomiasis in prehistoric and later human populations: a tentative reconstruction. In Diseases in Antiquity (Ed. by Brothwell and Sandson ) Ch. C. Thomas, Illinois.
Lambrecht F. L. (1973) Colour attraction of Glossina morsitans in N’gamiland, Botswana. J. trop. med. hyg. 76, 94–96.
Lamprey H. F., Glasgow J. P., Lee-Jones F. and Weitz B. (1962) A simultaneous census of the potential and actual food sources of the tsetse fly Glossina swynnertoni, Austen. J. Anim. Ecol. 31, 151–156.
Langley P. A. (1968) The effect of feeding the tsetse fly Glossina morsitans on impala blood. Bull. ent. Res. 58, 295–298.
Langley P. A. (1976) Initiation and regulation of ingestion by haematophagous arthropods. J. med. ent. 13, 121–130.
Langridge W. P. (1960) Scent attractants for tsetse flies. In Int. Sci. Comm. Tryp. Res., 8th Meeting.
Lehman D. L. (1961) Attempts at the selective cultivation of Trypanosoma rhodesiense, T. brucei and T. congolense. Ann. Trop. Med. Parasit. 55, 440–446.
Lumsden W. H. R. (1966) Estimation of serum Igm in the diagnosis of human trypanosomiasis. Trans. R. Soc. trop. Med. Hyg. 60, 125.
Lumsden W. H. R. (1967) Trends in research on the immunology of trypanosomiasis. Bull. Wld. Hlth. Org. 37, 167–175.
Lumsden W. H. R. and Evans D. A. (1976) Biology of the Kinetoplastida. Academic Press, London.
Maillot L. (1961) Répartition des Glossines et maladie du sommeil suivant les races géographiques. Bull. Soc. Path. Exot. 54, 856–869.
Marks A. D. (1966) Notes on the behaviour of tsetse flies (G. morsitans and G. pallidipes) with regard to impala. Interim report, Rhodesian Governiti., Dept. Vet. Serv., Tsetse and Trypanosomiasis Control Branch.
Mschelbwala A. S. (1972) Trypanosoma brucei infection in the haemocele of tsetse flies. Trans. R. Soc. trop. Med. Hyg. 66, 637–643.
Nash T. A. M. (1948) A note on the effect of high temperature on the pupal stages of Glossina in relation to the transmission rate of Trypanosomes. Ann. trop. Med. Parasit. 42, 30–32.
Otieno L. H. (1973) Trypanosoma brucei in the haemo-lymph of experimentally infected young Glossina morsitans. Trans. R. Soc. trop. Med. Hyg. 67, 886–887.
Prothero R. M. (1963) Population mobility and trypanosomiasis in Africa. Bull. Wld. Hlth. Org. 28, 615–623.
Rennisson B. D. and Robertson D. H. H. (1958) The use of carbon dioxide as an attractant for catching tsetse. E.A.T.R.O., Report 1958, p. 26.
Rice M. J., Galun R. and Margalit J. (1973) Mouthpart sensilla of the tsetse fly and their function. III. Labrocibarial sensilla. Ann. trop. med. parasti. 67, 109–116.
Rifkin M. R. (1978) Purification and identification of the trypanocidal factor from normal human serum. 4th Int. Congr. Parasit. Warsaw, 1978, section F, p. 42.
Rogers A. (1969) The use of dry ice in trapping tsetse. E.A.T.R.O. Report, (1969), 85–91.
Soltys M. A. (1963) Immunity in African Trypanosomiasis. Bull. Wld. Hlth. Org. 28, 753–761.
Soltys M. A. and Woo P. (1969) Multiplication of Trypanosoma brucei. Trans. R. Soc. trop. Med. Hyg. 63, 490–496.
Soltys M. A., Woo P. and Gillick A. C. (1969) A preliminary note on the separate and infectivity of tissue forms of Trypanosoma brucei. Trans. R. Soc. trop. Med. Hyg. 63, 495–496.
Terry R. J. (1976) Innate resistance to trypanosome infections. In Biology of the Kinetoplastida, (Ed. by Lumsden and Evans ), pp. 477–492. Academic Press, London.
Turner D. A. (1971) Olfactory perception of live host and carbon dioxide by the tsetse fly Glossina morsitans morsitans. Bull. ent. Res. 61, 75–96.
Turner O. A. and Invest J. F. (1973) Laboratory analyses of vision in tsetse flies (Dipt.: Glossinidae,. Bull. ent. Res. 62, 342–357.
Vale G. A. (1966) Mobile attractants for tsetse flies. Arnoldia 4, No. 33.
Vale G. A. (1974) New field methods for studying the responses of tsetse flies (Diptera: Glossinidae) to hosts. Bull. ent. Res. 64, 199–208.
Vale G. A. and Hargrove J. W. (1975) Field attraction of tsetse flies (Diptera: Glossinidae) to ox odour; the effect of dose. Trans. Rhodesian Sci. Assoc. 56, 46–50.
Vanden Berghe L. (1956) Aspect particular de la trypanosomiasis, maladie des pêcheurs, au Lac Tumba (Congo Belge.). Ann. Soc. Bel. Med. trop. 36, 185–190.
Vanden Berghe L. and Lambrecht F. L. (1962) Etude bioloque et écologique dans la région du Bugesera (Ruanda). Acad. R. Sci. Outre-Mer, Mem. Tome XIII.
Vanden Berghe L. and Lambrecht F. L. (1963) The epidemiology and control of human trypanosomiasis in Glossina morsitans fly belts. Am. J. trop. Med. Hyg. 12, 129–164.
Vickerman K. (1978) Antigenic variations in trypano-somes. Nature 273, 613–617.
Weinman D. (1959) Cultivation of trypanosomes. Trans. R. Soc. trop. Med. Hyg. 51, 560–561.
Weitz B. (1960) Feeding habits of bloodsucking arthropods. Exp. Parasit. 9, 63–82.
Weitz B. (1963) The feeding habits of Glossina. Bull. Wld. Hlth. Org. 28, 711–729.
Weitz B. (1970) Host of Glossina. In The African Trypanosomiasis (Ed. by Mulligan H. W.). Allen and Unwin, London.
Weitz B. and Jackson C. H. N. (1955) The host-animals of Glossina morsitans at Daga-Iloi. Bull. ent. Res. 46, 531–538.
Wijers D. J. B. (1958) Factors that may influence the infection rate of Glossina palpalis with Trypanosoma gambiense. I. Age of the fly at the time of the infected feed. Ann. trop. Med. Parasit. 52, 385–389.
Wijers D. J. B. and Willet K. G. (1960) Factors that may influence the infection rate of Glossina palpalis with Trypanosoma gambiense. II. The number and the morphology of the trypanosomes present in the blood of the host at the time of the infected feed. Ann. trop. Med. Parasit. 54, 341–350.
Willett K. C. (1966) Development of the peritrophic membrane in Glossina (tsetse flies) and its relation to infection with trypanosomes. Exp. Parasit. 18, 290–295.
Williamson J. (1956) The composition of tsetse fly saliva. I. A histochemical analysis. II. Analysis of amino acids and sugars by paper partition chromatography. Ann. trop. Med. Parasit. 50, 322–333, 334–344.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lambrecht, F.L. Ecological and Physiological Factors in the Cyclic Transmission of African Trypanosomiasis. Int J Trop Insect Sci 1, 47–54 (1980). https://doi.org/10.1017/S1742758400000126
Published:
Issue Date:
DOI: https://doi.org/10.1017/S1742758400000126