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Role of glucocorticoid receptor in serosa-involved gastric carcinoma after gastrectomy

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Glucocorticoid receptor (GR) was first found in the cytosol of gastric cancer tissue more than 15 years ago. At present, most gastric cancers are diagnosed at the advanced stage. To elucidate the role of GR in gastric cancer, the GR levels of the cancer tissue of 75 consecutive patients with grossly serosa-involved gastric carcinoma were determined by the dextran-coated charcoal method. The clinicopathologic characteristics and long-term survival duration were compared in patients with GR-positive and GR-negative cancer cells. We found that GR could be detected in the cytosol of cancer cells in 31 (41.3%) of the gastric cancer patients with a median concentration of 18.5 (range, 1.03–73.9) fmol/mg protein. No significant differences could be found in any clinicopathologic characteristic between the patients with GR-positive and GR-negative cancers. After multivariate analysis, gross Borrmann’s type, metastatic lymph node number, and GR positivity were the independent prognostic factors after gastrectomy for serosa-involved gastric carcinoma. GR-positive gastric cancer had a worse survival rate than GR-negative gastric cancer. Multimodality adjuvant therapies should be considered in patients with GR-positive serosa-involved gastric carcinoma.

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Authors and Affiliations

  1. From the Department of Surgery, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan

    Dah-Cherng Yeh M.D., Shao-Bin Cheng M.D., Cheng-Chan Yu M.D., Cheng-Chung Wu M.D., Tse-Jia Liu M.D. & Fang-Ku P’eng M.D. (F.A.C.S.)

  2. Departments of Surgery and Pathology, Taichung Veterans General Hospital, Department of Surgery, Chung-Shan Medical University, Taichung, Taiwan

    William-Lin Ho M.D.

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  1. Dah-Cherng Yeh M.D.
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  2. Shao-Bin Cheng M.D.
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  3. Cheng-Chan Yu M.D.
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  4. William-Lin Ho M.D.
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  5. Cheng-Chung Wu M.D.
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  6. Tse-Jia Liu M.D.
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  7. Fang-Ku P’eng M.D.
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Correspondence to Dah-Cherng Yeh M.D..

Additional information

Supported by Taichung Veterans General Hospital, grant numbers TCVGH 914607C and 924603C (to C.-C.W.).

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Yeh, DC., Cheng, SB., Yu, CC. et al. Role of glucocorticoid receptor in serosa-involved gastric carcinoma after gastrectomy. J Gastrointest Surg 10, 706–711 (2006). https://doi.org/10.1016/j.gassur.2005.10.004

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