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Deutsche Zeitschrift für Akupunktur

, Volume 51, Issue 4, pp 12–19 | Cite as

Placebokontrollierte Untersuchung zerebraler und vegetativer Effekte von Akupunktur an Di 4

  • Konrad Streitberger
  • J. Steppan
  • K. Plaschke
  • C. Maier
  • H. Hill
  • J. Backs
Originalia | Original Articles

Zusammenfassung

Hintergrund und Zielsetzung

Unter Akupunktur wurden bislang verschiedene neurophysiologische Effekte beobachtet. Bislang gibt es noch keine Studie, in der die Korrelation von zentralnervösen Veränderungen mit vegetativen Effekten placebokontrolliert untersucht wurde. Unter Berücksichtigung einer verlässlichen Verblindung der Probanden war Ziel dieser Studie, spezifische zerebrale und vegetative Effekte von Verum-Akupunktur (VA) am Akupunkturpunkt Di 4 (Hegu) im Vergleich zu Placebo-Akupunktur (PA) zu untersuchen.

Methodik

Gesunde Probanden erhielten beidseits entweder Akupunktur an Di 4 mit einer Verum-Nadel oder Akupunktur an einem Nicht-Akupunkturpunkt mit einer Placebo-Nadel. Parallel dazu wurden EEG und EKG abgeleitet. Es folgte eine Befragung zu Schmerzen, Hautdurchstich und vegetativen Effekten.

Ergebnisse

Das Gefühl des Hautdurchstichs war nicht signifikant unterschiedlich (p = 0,057). Vegetative Effekte und De Qi-Gefühl traten jedoch signifikant häufiger bei VA auf (p = 0,022). Das Schmerzempfinden war bei VA-Stimulation erhöht gegenüber PA (p < 0,01). Die Verum-Stimulation führte zu einer Erhöhung der okzipitalen EEG-Alpha-Power (p < 0,03). Der Anstieg der Alpha 1-Wellen war begleitet von einem Absinken der Theta-Wellen. Der Alpha 1/Theta-Quotient verschob sich zugunsten von Alpha 1 (p < 0,04). Parallel dazu kam es zu einem kurzfristigen Anstieg des EKG-Quotienten zwischen Low-Frequency (LF) und High-Frequency (HF) (p < 0,02), gefolgt von einer Erhöhung der HF-Power (p < 0,04).

Schlussfolgerung

PA ist für die Probanden nicht von VA unterscheidbar. Die während VA-Stimulation gemessenen Veränderungen im EEG und EKG geben Hinweise auf eine Modulation der zerebralen Funktionen durch vegetative Akupunktureffekte im Unterschied zu PA.

Schlüsselwörter

Akupunktur Di 4 EEG EKG Placebo 

Placebo-controlled Investigation of Cerebral and Vegetative Effects of Acupuncture at LI 4

Abstract

Background and Aims

Many neurophysiologic effects have been observed during acupuncture. So far there is no placebo-controlled trial studying the correlation between changes in the central nervous system and vegetative effects. In consideration of a reliable blinding of the volunteers, the aim of this study was to examine specific cerebral and vegetative effects of verum-acupunture (VA) compared to placebo-acupuncture (PA).

Methods

Healthy volunteers received either VA at LI 4 (Hegu) with a verum-needle or PA at a non-acupuncture point with a placebo needle. EEG and ECG recordings were performed in parallel followed by an evaluation of pain, skin penetration and vegetative effects.

Results

The feeling of skin penetration was not significantly different (p = 0.057). Vegetative effects and Deqi occurred significantly more often during VA (p = 0.022). Pain was increased during VA-stimulation compared to PA (p > 0.01). Verum stimulation markedly increased occipital EEG power (p < 0.03). The increase in the fast alpha1 waves was accompanied by a decrease in the theta frequencies and the ratio alpha1/theta was shifted to the benefit of alpha1 (p < 0.04). This was paralleled by a short increase of the ECG ratio between low frequency (LF) and high frequency (HF) (p < 0.02), followed by an increase of HF-power (p < 0.04).

Conclusions

Volunteers were unable to distinguish between VA and PA. The EEG and ECG changes measured during VA stimulation are pointing towards a modulation of cerebral functions by vegetative acupuncture effects compared to PA.

Keywords

Acupuncture LI 4 EEG ECG placebo 

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2008

Authors and Affiliations

  • Konrad Streitberger
    • 1
  • J. Steppan
    • 3
  • K. Plaschke
    • 3
  • C. Maier
    • 3
  • H. Hill
    • 3
  • J. Backs
    • 2
  1. 1.Hochschule HeilbronnBaden-WürttembergDeutschland
  2. 2.Innere MedizinMedizinische Fakultät der Universität HeidelbergHeidelbergDeutschland
  3. 3.AnästhesiologieUniversität HeidelbergHeidelbergDeutschland

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