Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols

Abstract

The ethanol crude extract from cashew (Anacardium occidentale L. Anacardiaceae) displayed significant antiplasmodial activity (IC50 0.577 μg/ml). Liquid chromatography-high resolution Mass spectrometry analysis was performed to identify the main compounds existing in the ethanol extract. The occurrence of anacardic acids, cardols, and 2-methylcardols derivatives was confirmed in the extract. The IC50 obtained, when the main isolated compounds were evaluated in Plasmodium falciparum D6 strain, ranged from 5.39 μM to >100 μM. Tested here for the first time, the data showed that cardol triene 1 (IC50 = 5.69 μM) and 2-methylcardol triene 4 (IC50 = 5.39 μM) demonstrated good antimalarial activity. In conclusion, Anacardium occidentale nuts presented relevant biological potential, and further studies should be considered.

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Correspondence to Patricia M. Pauletti.

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Authors’ contributions

VMMG and TAA contributed by running the laboratory work. MG identified the plant material. AHJ, WRC, and MLAS collaborated with the phytochemical investigation. MJS cooperated with the biological studies. PMP wrote the paper with contributions from AHJ, WRC, and MLAS. PMP and MKR designed the study and critically read the manuscript. All the authors have read the final manuscript and approved the submission.

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Gimenez, V.M.M., Alvarenga, T.A., Groppo, M. et al. Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols. Rev. Bras. Farmacogn. 29, 36–39 (2019). https://doi.org/10.1016/j.bjp.2018.11.003

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Keywords

  • Anacardic acid
  • Antiplasmodial
  • Cardol
  • Cashew
  • Methylcardol