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Chemical constituents from ethanol extract of Polyalthia rumphii branches and their cytotoxicity evaluation

Revista Brasileira de Farmacognosia volume 28, pages 235–238 (2018)Cite this article

Abstract

Twelve known compounds, including eight alkaloids, three lignans and one gossypol derivative, were isolated from the branches of Polyalthia rumphii (Blume ex Hensch.) Merr., Annonaceae. The chemical structures were determined by spectroscopic methods and comparison with literature data. All the isolates were evaluated the cytotoxicity against three human cancer cell lines: Hela, MCF-7 and A549, the results showed that partial of isolates displayed weak cytotoxicities with the IC50 values ranging from 25 to 40 μ/ml.

References

  • Chen, C.Y., Chang, F.R., Shih, Y.C., Hsieh, T.J., Chia, Y.C., Tseng, H.Y., Chen, H.C., Chen, S.J., Hsu, M.C., Wu, Y.C., 2000. Cytotoxic constituents of Polyalthia longifolia var. pendula. J. Nat. Prod. 63, 1475–1478.

    CAS  Article  PubMed  Google Scholar 

  • Editorial Board of FOC, 2011. Flora of China, vol. 19. Science Press, Beijing, pp. 696.

    Google Scholar 

  • Gu, Q., Cai, Y.N., Yang, G.M., Cai, B.C., Pan, Y., 2013. Study on chemical constituents and antitumor activity of Oxytropic falcata. Chin. J. Exp. Trad. Med. Form. 19, 72–75.

    CAS  Google Scholar 

  • Lee, J., Kim, N.H., Nam, J.W., Lee, Y.M., Jang, D.S., Kim, Y.S., Nam, S.H., Seo, E.K., Yang, M.S., Kim, J.S., 2010. Scopoletin from the flowerbuds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis ex vivo. Arch. Pharm. Res. 33, 1317–1323.

    CAS  Article  PubMed  Google Scholar 

  • Machana, S., Weerapreeyakul, N., Barusrux, S., Thumanu, K., Tanchanuch, W., 2012. Synergistic anticancer effect of the extracts from Polyaithia evecta caused apoptosis in human hepatoma (HepG2) cells. Asian Pac. J. Trop. Biomed. 2, 589–596.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mo, X.Y., Mai, J.B., 2012. Chemical constituents of ethyl acetate extract part of Stelmatocrypton khasianum. Chin. J. Exp. Trad. Med. Form. 18, 61–63.

    CAS  Google Scholar 

  • Niu, Z.G., Chen, H.H., Chen, T.T., Xia, Q., Li, G.N., 2015. Synthesis, crystal structure and IR spectra of binuclear Cr (III) Complex with 2-(1H-Tetrazol-5-yl) pyridine ligand. J. Hainan Norm. Univ. (Nat. Sci.) 28, 176–179.

    Google Scholar 

  • Shono, T., Ishikawa, N., Tourne, K., Arai, M.A., Masu, H., Koyano, T., Kowithayakorn, T., Ishibashi, M., 2016. Cerasoidine, a bis-aporphine alkaloid isolated from Poiyaithia cerasoides during screening for Wnt signal inhibitors. J. Nat. Prod. 79, 2083–2088.

    CAS  Article  PubMed  Google Scholar 

  • Tulake, A., Jiang, Y., Tu, P.F., 2012. Nine lignans from Artemisia absinthium L. J. Chin. Pharm. Sci. 21, 360–364.

    CAS  Article  Google Scholar 

  • Wang, D.F., Chou, G.X., Zhao, N.Y., Zhang, T., Xu, H., 2012a. Study on chemical constituents in stems of Dendrobium nobile. Chin. Trad. Herb. Drugs 43, 1492–1945.

    CAS  Google Scholar 

  • Wang, L., Chen, G.Y., Han, C.R., Yuan, Y., Yang, B., Zhang, Y., Wang, J., Zhong, X. Ci, Huang, X., 2011. Two novel alkaloids from the stem of Saprosma hainanense and their cytotoxic activities in vitro. Chem. Pharm. Bull. 59, 338–340.

    CAS  Article  PubMed  Google Scholar 

  • Wang, Q.H., Peng, K., Tan, L.H., Dai, H.F., 2010. Aquilarin A, a new benzenoid derivative from the fresh stem of Aquilaria sinensis. Molecules 15, 4011–4016.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  • Wang, T.S., Luo, Y.P., Wang, J., He, M.X., Zhong, M.G., Li, Y., Song, X.P., 2013. (+)- Rumphiin and polyalthurea, new compounds from the stems of Poiyaithia rumphii. Nat. Prod. Commun. 8, 1427–1429.

    CAS  PubMed  Google Scholar 

  • Wang, T.S., Yuan, Y., Wang, J., Han, C.R., Chen, G.Y., 2012b. Anticancer activities of constituents from the stem oiPolyalthia rumphii. Pak. J. Pharm. Sci. 25, 353–356.

    PubMed  Google Scholar 

  • Wu, G.P., Ying, H.C., Yan, Z.L., Guo, Z.M., Hou, J.Y., Zhu, C.Q., Shi, D.X., Bian, J., 1989. Synthesis and antifertility actions of gossypol derivatives and phenol aldehydes. Acta Pharm. Sin. 24, 502–511.

    CAS  Google Scholar 

  • Wu, Y.C., Duh, C.Y., Wang, S.K., Chen, K.S., Yang, T.H., 1990. Two new natural azaflu-orene alkaloids and a cytotoxic aporphine alkaloid from Poiyaithia longifolia. J. Nat. Prod. 53, 1327–1331.

    CAS  Article  PubMed  Google Scholar 

  • Yu, Z.X., Fu, Y.H., Chen, G.Y., Song, X.P., Han, C.R., Li, X.B., Song, X.M., Wu, A.Z., Chen, S.C., 2016. New clerodane diterpenoids from the roots of Poiyaithia laui. Fitoterrapia 111, 36–41.

    CAS  Article  Google Scholar 

  • Yuan, Y., Huang, G.J., Wang, T.S., Chen, G.Y., 2011. In vitro screening of five Hainan plants of Poiyaithia (Annonaceae) against human cancer cell lines with MTT assay. J. Med. Plants Res. 15, 837–841.

    Google Scholar 

  • Yusoff, M., Hamid, H., Houghton, P., 2014. Anticholinesterase inhibitory activity of quaternary alkaloids from Tinospora crispa. Molecules 19, 1201–1211.

    Article  PubMed  PubMed Central  Google Scholar 

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  1. These authors contributed equally to this manuscript.

Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, China

    Tianshan Wang, Yanping Liu, Youping Luo, Xiang Li, Yujie Zhou, AiPing Yang, Zhengmeng Yan, Ling Ye, Siwei Chen, Jinshuai Fu & Xianzhi Jiao

  2. Key Laboratory of Tropical Medicinal Plant Chemistry (Hainan Normal University), Ministry of Education, Haikou, China

    Tianshan Wang, Yanping Liu & Youping Luo

  3. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Science, Haikou, China

    Xiaopeng Wu

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  1. Tianshan Wang
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  2. Xiaopeng Wu
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Corresponding author

Correspondence to Tianshan Wang.

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Authors’ contributions

TSW and XPW contributed equally to this paper on structural determination, writing this paper and running the laboratory work; YPL conducted the anticancer activity; YPL did the NMR investigations; XL, YJZ, APY, ZMY, LeY, SWC, JSF and XZJ (undergraduate students) carried out the extraction, isolation and purification.

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Wang, T., Wu, X., Liu, Y. et al. Chemical constituents from ethanol extract of Polyalthia rumphii branches and their cytotoxicity evaluation. Rev. Bras. Farmacogn. 28, 235–238 (2018). https://doi.org/10.1016/j.bjp.2018.03.004

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  • DOI: https://doi.org/10.1016/j.bjp.2018.03.004

Keywords

  • Alkaloids
  • Lignan
  • Gossypol derivative
  • Cytotoxic activity
  • Polyalthia rumphii