Evaluation of the effects of passion fruit peel flour (Passiflora edulis fo. flavicarpa) on metabolic changes in HIV patients with lipodystrophy syndrome secondary to antiretroviral therapy

Abstract

This study evaluated the effects of using passion fruit peel flour together with diet therapy and counseling in 36 patients with HIV lipodystrophy who were in an ambulatory clinic in a university hospital. The patients were divided into two groups. One received 30 g of passion fruit peel flour daily for 90 days and diet therapy counseling. The other group received only diet therapy counseling. The metabolic changes were analyzed before and after the intervention, with a significance level predetermined at p≤0.05. The use of passion fruit peel flour was effective in reducing total cholesterol and triacylglycerides after 30 days. The concentrations of LDL-C decreased, while HDL-C increased in the blood of lipodystrophy patients after 90 days passion fruit peel flour treatment. No significant differences in food consumption were seen between groups. The use of 30g of passion fruit peel flour for 90 days together with diet therapy counseling was effective in improving plasma concentrations of total cholesterol. LDL-C. HDL-C and triacylglycerides.

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Authors

Contributions

SSFM, RMFL and AUOSS designed the experiments and carried them out. SSFM wrote the first draft. RMFL is her advisor. She conceived the project, and did the statistical analyses. RES added more back ground information, rewrote the paper and submitted it and revised it based on reviewers’ comments. TD did the methanol extractions. PS and SH acquired the FTIR and UV—Vis spectra andanalyzed them. RL did the NMR analyses.

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Correspondence to Robert E. Smith.

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Marques, S.d.S.F., Libonati, R.M.F., Sabaa-Srur, A.U.O. et al. Evaluation of the effects of passion fruit peel flour (Passiflora edulis fo. flavicarpa) on metabolic changes in HIV patients with lipodystrophy syndrome secondary to antiretroviral therapy. Rev. Bras. Farmacogn. 26, 420–426 (2016). https://doi.org/10.1016/j.bjp.2016.03.002

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Keywords

  • Passion fruit peel flour
  • HIV patients
  • Lipodystrophy syndrome
  • Dyslipidemia