Iridoid and phenylethanoid glycosides from the aerial part of Barleria lupulina

Abstract

A new iridoid glycoside, barlupulin C methyl ester (1), together with two known phenylethanoid glycosides (2 and 3) and three known simple phenolic glycosides (4-6) were isolated from the aerial parts of Barleria lupulina Lindl., Acanthaceae. The structure of the new compound (1) was elucidated through ID and 2D NMR spectroscopic data, and HR-ESIMS. Interestingly, compound (1) has a formate group attached to the C-6 hydroxy group of the glucose unit. Compounds 2-6 were identified as poliumoside (β), decaffeoylacteoside (3), protocatechuic acid 4-O-β-glucoside (4), vanillic acid 4-O-β-glucoside (5), and leonuriside A (6) on the basis of NMR spectroscopic data analyses and comparison with those reported in the literature. Compounds 3-6 were isolated from B. lupulina for the first time.

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Acknowledgements

This publication was made possible by grant number R01AT007022 (to D.S. and S.C.) from National Center for Complementary and Integrative Health (NCCIH), then the National Center for Complementary and Alternative Medicine (NCCAM), at the National Institutes of Health, USA. This research was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2015R1C1A1A02037383).

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SRL contributed to the experiment and wrote the manuscript. JC reviewed the manuscript. DRS conducted the experiment. SC and KHK contributed to the design of the study and critical reading of the manuscript. All the authors have read the final manuscript and approved the submission.

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Correspondence to Shugeng Cao.

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The authors declare no conflicts of interest.

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Lee, S.R., Clardy, J., Senger, D.R. et al. Iridoid and phenylethanoid glycosides from the aerial part of Barleria lupulina. Rev. Bras. Farmacogn. 26, 281–284 (2016). https://doi.org/10.1016/j.bjp.2016.01.002

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Keywords

  • Barleria lupulina
  • Acanthaceae
  • Iridoid glycoside
  • Phenolic glycoside