Determination of the regulatory properties of Yucca schidigera extracts on the biochemical parameters and plasma hormone levels associated with obesity

Abstract

Yucca schidigera Ortgies, Asparagaceae, is a herbaceous plant. Due to the high saponin content the powdered branches and leaves are used as natural food additive for human and animal. The aim of this study was to investigate the effects of Y. schidigera extracts on plasma leptin, ghrelin, adiponectin, insulin, thyroid hormones and some biochemical parameters in mice fed a high-fat diet. Male Swiss Albino mice were divided into seven equal groups. Group I (negative control group) was given standard diet; Group II was given high-fat diet; Group III was given high-fat diet with carboxymethylcellulose; Groups IV-VII were given hexane, petroleum ether, ethyl acetate, and methanol extracts of Y. schidigera and high-fat diet via gastric gavage for 60 days. High-fat diet significantly increased plasma leptin, insulin, free T3 hormone, glucose, cholesterol, low-density lipoprotein, triacylglyceride, aspartate aminotransferase and alanine aminotransferase levels, and significantly decreased plasma ghrelin, adiponectin and free T4 hormone levels. On the other hand, hormone levels, lipid profile and biochemical parameters were improved by the administration of the PE extract. Y. schidigera extracts could be used as preventive medicine in nutritional disorders via regulating energy metabolism and hormonal functions.

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Acknowledgement

This study was supported by Afyon Kocatepe University Scientific Research Projects Commission with the Project number of 09.VF.11.

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Contributions

IK, FK and NBS contributed to biochemical analyses. EKA and IS contributed in the selection of the plant material, preparation of the plant extracts and writing the manuscript. SI and AE contributed in the application of the test materials to the animals. All the authors have read the final manuscript and approved the submission.

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Correspondence to Ismail Kucukkurt.

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The authors declare no conflicts of interest.

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Kucukkurt, I., Akkol, E.K., Karabag, F. et al. Determination of the regulatory properties of Yucca schidigera extracts on the biochemical parameters and plasma hormone levels associated with obesity. Revista Brasileira de Farmacognosia 26, 246–250 (2016). https://doi.org/10.1016/j.bjp.2015.12.005

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Keywords

  • Adiponectin
  • Ghrelin
  • Insulin
  • Leptin
  • Obesity
  • Mice