The hypolipidemic activity of friedelin isolated from Azima tetracantha Lam., Salvadoraceae, was studied in Triton WR-1339 and high-fat diet-induced hyperlipidemic rats. In Triton WR-1339 induced hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) showed a significant (p < 0.01) lipid-lowering effect as assessed by reversal of plasma levels of total cholesterol (TC), triacylglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). In high-fat diet fed hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) caused lowering of lipid levels in plasma and liver. The hypolipidemic activity of friedelin was compared with fenofibrate, a known lipid-lowering drug, in both models.
Antonisamy, P., Duraipandiyan, V., Ignacimuthu, S., 2011. Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models. J. Pharm. Pharmacol. 63, 1070–1077.
Baby, S., Anuradha, R., 2013. Hypolipidaemic activity of Punica granatum flowers on hydrogenated groundnut oil induced hyperctiolesterolemic rats. Int. Res. J. Pharm. Appl. Sci. 3, 136–139.
Ban, S.J., Rico, C.W., Um, I.C., Kang, M.Y., 2012. Antihyperlipidemic effects of hydrox-yethyl methylcellulose with varying viscosity in mice fed with high fat diet. Food Res. Int. 48, 1–6.
Basuny, A.M.M., Arafat, S.M., El-Marzooq, M.A., 2012. Antioxidant and antihyperlipidemic activities of anthocyanins from eggplant peels. J. Pharm. Res. Rev. 2, 50–57.
De Graat, J., De Sauvage, N.P.R., Van Dam, M., Belsey, E.M., Kastelein, J.J., Haydn, P.P., Stalenhoef, A.F., 2002. Consumption of tall oil-derived phytos-terol in a chocolate matrix significantly decrease plasma total and low-density lipoprotein-cholesterol levels. Br. J. Nutr. 88, 479–488.
Duraipandiyan, V., Gnanasekar, M., Ignacimuthu, S., 2010. Antifungal activity of triterpenoid isolated from Azima tetracantha leaves. Folia Histochem. Cytobiol. 48, 311–313.
Friedewald, W.T., Levy, R.I., Fredrickson, D.S., 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18, 499–502.
Ghatak, S.B., Panchal, S.J., 2012. Antihyperlipidemic activity of oryzanol, isolated from crude rice bran oil, on Triton WR-1339-induced acute hyperlipidemia in rats. Rev. Bras. Farmacogn. 22, 642–648.
Guido, S., Joseph, T., 1992. Effect of chemically different calcium antagonists on lipid profile in rats fed on a high fat diet. Indian J. Exp. Biol. 30, 292–294.
Harnafi, H., Bouanani Nel, H., Aziz, M., Serghini Caid, H., Ghalim, N., Amrani, S., 2007. The hypolipidaemic activity of aqueous Erica multiflora flowers extract in Triton WR-1339 induced hyperlipidaemic rats: a comparison with fenoflbrate. J. Ethnopharmacol. 109, 156–160.
Harnafi, H., Caid, H.S., Bouanani, N.H., Aziz, M., Amrani, S., 2008. Hypolipemic activity of polyphenol-rich extracts from Ocimum basilicum in Triton WR-1339-induced hyperlipidemic mice. Food Chem. 108, 205–212.
Huang, H., Mai, W., Liu, D., Hao, Y., Tao, J., Dong, Y., 2008. The oxidation ratio of LDL: a predictor for coronary artery disease. Dis. Mark. 24, 341–349.
Jiao, J., Zhang, Y., Lou, D., Wu, W., Zhang, Y., 2007. Antihyperlipidemic and antihypertensive effect of a triterpenoid-rich extract from bamboo shavings and vasodilator effect of friedelin on phenylephrine-induced vasoconstriction in thoracic aortas of rats. Phytother. Res. 21, 1135–1141.
Jo, S.P., Kim, J.It, Lim, Y.H., 2014. Antihyperlipidemic effects of stilbenoids isolated from Moms alba in rats fed a high-cholesterol diet. Food Chem. Toxicol. 65, 213–218.
Kirtikar K.R., Basu B.D., An I.C.S., 1984. Indian Medicinal Plants, second ed. Bishen Singh Mahendra Pal Singh, Dehra Dun, pp. 1541.
Levine, S., Saltzman, A., 2007. A procedure for inducing sustained hyperlipemia in rats by administration of a surfactant. J. Pharmacol. Toxicol. Methods 55, 224–226.
Li, T., Li, S., Du, L., Wang, N., Guo, M., Zhang, J., Yan, F., Zhang, H., 2010. Effects of haw pectic oligosaccharide on lipid metabolism and oxidative stress in experimental hyperlipidemia mice induced by high-fat diet. Food Chem. 121, 1010–1013.
Nargis Begum, T., Muhammad Ilyas, M.H., Kalavathy, S., Vijaya Anand, A., Sampath Kumar, P., Senthil, R., 2009. Effects of ethanolic leaf extract ofAzima tetracantha Lam. on Ehrlich Ascites carcinoma tumour bearing mice. Res. J. Med. Med. Sci. 4, 351–354.
Natarajan, It, Rashid, T., Shuhaib, C.K., Balu, V., 2014. Azima tetracantha Lam. against causative agents in diabetic foot infections. Innovare J. Health Sci. 2, 9–12.
Noorani, A.A., Dwivedi, G., Kale, M.K., 2011. Antihyperlipidemic activity of Rimona-bant on high cholesterol diet induced hyperlipidemia in rats. Pharmacol. Online 1, 1212–1220.
Oliveira, H.C., Dos Santos, M.P., Grigulo, R., Lima, L.L., Martins, D.T.O., Lima, J.C.S., Stoppiglia, L.F., Lopes, C.F., Kawashita, N.F., 2008. Antidiabetic activity of Vatairea macrocarpa extract in rats. J. Ethnopharmacol. 115, 515–519.
Roux, S., Sable, E., Porsolt, R.D., 2004. Primary observation (Irwin) test in rodents for assessing acute toxicity of a test agent and its effect on behavior and physiological function. Curr. Protoc. Toxicol. 10, 1–23.
Sagar, P.M., Rekha, D.K., Farid, M., Sachin, L.B., 2012. Therapeutic approaches to drug targets in hyperlipidemia. Biomedicine 2, 137–146.
Srinivasa Rao, B.D., Saileela, C.H., 2013. Antihyperlipidemic activity of methanolic extract of Rhinacanthus nasutus. Int. J. Res. Pharm. Chem. 3, 708–711.
Stephen Irudayaraj, S., Sunil, C., Duraipandiyan, V., 2013. In vitro antioxidant and antihyperlipidemic activities of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet induced hyperlipidemic rats. Food Chem. Toxicol. 60, 135–140.
Sunil, C., Ignacimuthu, S., Kumarappan, C., 2012. Hypolipidemic activity of Symptoms cochinchinensis S. Moore leaves in hyperlipidemic rats. J. Nat. Med. 66, 32–38.
Thendral Hepsibha, B., Sathiya, S., Saravana Babu, C., Premalakshmi, V., Sekar, T., 2011. In vitro studies on antioxidant and free radical scavenging activities of Azima tetracantha Lam leaf extracts. Indian J. Sci. Technol. 3, 571–577.
Vembu, S., Sivanasan, D., Prasanna, G., 2012. Effect of Phoenix deactylifera on high fat diet induced obesity. J. Chem. Pharm. Res. 4, 348–352.
Verma, P.R., Deshpande, S.A., Kamtham, Y.N., Vaidya, L.B., 2012. Hypolipidemic and antihyperlipidemic effects from an aqueous extract of Pachyptera hymenaea (DC.) leaves in rats. Food Chem. 132, 1251–1257.
Zarzecki, M.S., Araujo, S.M., Bortolotto, V.C., Trindade de Paula, M., Jesse, C.R., Marina, M., 2014. Hypolipidemic action of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL/6 mice. Toxicol. Rep. 1, 200–208.
The Project was fully financially supported by King Saud University, through Vice Deanship of Research Chairs.
The authors declare no conflicts of interest.
About this article
Cite this article
Duraipandiyan, V., Al-Dhabi, N.A., Irudayaraj, S.S. et al. Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats. Rev. Bras. Farmacogn. 26, 89–93 (2016). https://doi.org/10.1016/j.bjp.2015.07.025
- High-fat diet model
- Triton WR-1339