Antimicrobial activity of the myrsinoic acid A from Myrsine coriacea and the semi-synthetic derivatives


The antimicrobial activity of the myrsinoic acid A isolated from Myrsine coriacea (Sw.) R.Br. ex Roem. Schult., Primulaceae, and a two semi-synthetics derivatives was tested against Bacillus subtilis, Escherichia coli, Salmonella enterica subsp. enterica serovar typhi, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Micrococcus luteus, Candida albicans, Candida krusei and Candida tropicalis. The microdilution method was used for the determination of the minimum inhibitory concentration during evaluation of the antimicrobial activity. The myrsinoic acid A showed no activity against the selected microorganisms but the hydrogenated and acetylated derivatives were active against B. subtilis, E. coli, S. aureus and P. aeruginosa.


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This work was supported by the FAPESP (grant number 2006/58043-3), CNPq and CAPES by student sponsorships. The authors acknowledge M. F. Freitas by plant identification.

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MCMB and GSOC (PhD students) contributed in collecting plant sample, running the laboratory work, in the synthesis of derivatives, analysis of the data and drafted the paper. APT contributed to biological studies, analysis of the data and drafted the paper.JBF, MFGFS, PCV, ACSM contributed to chromatographic analysis,designed the study, supervised the laboratory work and contributed to critical reading of the manuscript. All the authors have read the final manuscript and approved the submission.

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Correspondence to Joao Batista Fernandes.

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de Burger, M.C.M., Terezan, A.P., de Oliveira Cunha, G.S. et al. Antimicrobial activity of the myrsinoic acid A from Myrsine coriacea and the semi-synthetic derivatives. Rev. Bras. Farmacogn. 25, 451–454 (2015).

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  • Myrsine coriace
  • Antimicrobial activity
  • Primulaceae
  • Myrsinoic acid A