Alkaloids isolated from the leaves of atemoya (Annona cherimola × Annona squamosa)

Abstract

Atemoya is an interspecific annonaceous hybrid between Annona cherimola Mill. and Annona squamosa L. Its phytochemical investigation led to seven alkaloids, including two aporphine (anonaine and asimilobine), three oxoaporphine (lanuginosine, liriodenine and lysicamine) and two proaporphine (pronuciferine and stepharine). These alkaloids were identified by a series of spectrometric methods, mainly MS and NMR (1D and 2D), as well as by comparison with literature data. Our findings showed that this species is an important source of aporphine alkaloids and have high relationship with other Annona species.

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Acknowledgments

The authors are grateful to CNPq (Processes: 470594/2013-6, 442209/2014-2, and 303587/2014-8), CAPES, FINEP and UFPR for financial support and fellowships as well as to Centro de Referência para Recuperação de Áreas Degradadas (CRAD/UNIVASF) for botanical identification of the plant material.

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SVR, XPN and MFCS were responsible for the collection, preparation of the extracts and phytochemical studies. EVC, AB and LMD conducted the experiments of nuclear magnetic resonance. JCT, GGO and NPL conducted the experiments of mass spectrometry. EVC and JRGSA analyzed and interpreted the data, and drafted the manuscript. All the authors have read the final manuscript and approved the submission.

Corresponding author

Correspondence to Jackson R. G. da Silva Almeida.

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The authors declare no conflicts of interest.

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Rabêlo, S.V., Costa, E.V., Barison, A. et al. Alkaloids isolated from the leaves of atemoya (Annona cherimola × Annona squamosa). Rev. Bras. Farmacogn. 25, 419–421 (2015). https://doi.org/10.1016/j.bjp.2015.07.006

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Keywords

  • Annonaceae
  • Annona
  • Alkaloids
  • Atemoya
  • Caatinga