Abstract
A new phenylethyl chromenone, cucumin S [(R)-5, 7-dihydroxy-2-[1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]chromone] (1), along with five known compounds: 5, 7-dihydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone (2), 5, 7-dihydroxy-2-[2-(3, 4-dihydroxyphenyl)ethyl]chromone (3), luteolin (4), quercetin (5), and 7-glucosyloxy-5-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone (6) were isolated from the EtOAc fraction of Cucumis melo var. reticulatus Ser., Cucurbitaceae, seeds. Their structures were determined by spectroscopic means (1D and 2D NMR), as well as HRESIMS, optical rotation measurement, and comparison with literature data. The isolated compounds 1-6 were assessed for their antioxidant activity using DPPH assay. Compounds 3, 4, and 5 showed potent activities compared to propyl gallate at concentration 100 uM.
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SRMI and GAM contributed in collecting the plant sample, running the laboratory work, analysis of the spectroscopic data, and writing the manuscript. GAM carried out the antioxidant activity measurement. SRMI has revised and approved the submission.
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Ibrahim, S.R.M., Mohamed, G.A. Cucumin S, a new phenylethyl chromone from Cucumis melo var. reticulatus seeds. Rev. Bras. Farmacogn. 25, 462–464 (2015). https://doi.org/10.1016/j.bjp.2015.06.006
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DOI: https://doi.org/10.1016/j.bjp.2015.06.006