New lycosinine derivative from Hippeastrum breviflorum

Abstract

A new lycosinine derivative, 9-O-demethyllycosinine B, was isolated from the native Brazilian Hippeastrum breviflorum Herb., Amaryllidaceae, along with the well-known alkaloids lycosinine B and lycorine. The structure of the new compound was established by physical and spectroscopic methods. 9-Odemethyllycosinine B is the third lycosinine variant identified in the Amaryllidaceae family.

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Acknowledgments

This investigation was supported by grants of CAPES, FAPERGS CNPq (Brazil). JPA the Agencia Española de Cooperación Internacional para el Desarollo (BECASMAEC-AECID) for a doctoral fellowship. JASZ and ATH are grateful to CNPq for researcher fellowships.

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Authors

Contributions

CS carried out the phytochemical process for isolation and wrote the manuscript. RBG and JPA also contributed in writing the manuscript. SB and EJO performed NMR analysis and MS helped in the collection and identification of the plant material. MVA and ATH contributed to the critical reading the manuscript. CS, RBG, JPA, SB, JASZ and JB were responsible for the spectral analysis and critical reading of the text. All authors have approved the final version for publishing.

Corresponding author

Correspondence to José Ângelo Silveira Zuanazzi.

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The authors declare no conflicts of interest.

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Sebben, C., Giordani, R.B., de Andrade, J.P. et al. New lycosinine derivative from Hippeastrum breviflorum. Rev. Bras. Farmacogn. 25, 353–355 (2015). https://doi.org/10.1016/j.bjp.2015.06.005

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Keywords

  • Hippeastrum breviflorum
  • Amaryllidaceae
  • Alkaloids
  • Lycorine
  • 9-O-demethyllycosinine B
  • Lycosinine B