Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda

Abstract

Arrabidaea brachypoda Bureau, Bignoniaceae, known as “cipó-una”, is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3β-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3β-estearioxy-olean-12-ene in animals. We observed that 3β-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3β-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect in different tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use.

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Acknowledgements

The authors acknowledge financial support from FAPESP, FAPEMIG and CAPES.

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CQR, FCV, FVS-C and GPC participated in study concept and design, acquisition of data, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript for important intellectual content. WV, AG-P and MHS participated in study concept and design, acquisition of data, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript for important intellectual content, administrative, technical, or material support, and study supervision.

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Correspondence to Marcelo H. dos Santos.

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da Rocha, C.Q., Vilela, F.C., Santa-Cecília, F.V. et al. Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda. Rev. Bras. Farmacogn. 25, 228–232 (2015). https://doi.org/10.1016/j.bjp.2015.03.005

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Keywords

  • Arrabidaea brachypoda
  • Inflammation
  • Natural product
  • Pain
  • Triterpene