Constituents of Corynaea crassa “Peruvian Viagra”

Abstract

A phytochemical investigation of methanol and n-hexane extracts of tuber/roots of Corynaea crassa Hook. f., Balanophoraceae, led to the isolation and characterization of β-sitosterol, lupenone, β-amyrone, lupeol, and β-amyrine. Unusual complex 1:1 mixtures of lupenone/β-amyrone and lupeol/β-amyrine obtained from the extracts were identified by NMR and HR-MS experiments. The structure of the 1:1 lupenone/β-amyrone mixture was confirmed by X-ray analysis. These triterpene ketone derivatives, only distinguished either by 5- or 6-membered E ring, co-crystallize in one common unit cell in the solid state.

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Acknowledgments

The authors are grateful to Mrs. Ramona Oehme (University of Leipzig, Institute of Analytical Chemistry, Germany) for the measurement of the MS spectra.

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GRMG (PhD student) contributed in collecting plant sample and identification, running the laboratory work, and drafted the paper; LH did the NMR investigations; JS performed the X-ray analysis; RWB contributed in collecting plant sample and identification. All the authors have read the final manuscript and approved the submission.

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Correspondence to Gonzalo R. Malca Garcia.

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Malca Garcia, G.R., Hennig, L., Sieler, J. et al. Constituents of Corynaea crassa “Peruvian Viagra”. Rev. Bras. Farmacogn. 25, 92–97 (2015). https://doi.org/10.1016/j.bjp.2015.02.007

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Keywords

  • β-Amyrone
  • β-Amyrine
  • Corynaea crassa
  • Huanarpo
  • Lupenone
  • Lupeol/β-sitosterol